Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0268596 (
EMA
)
2,520
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ecological momentary assessment (
EMA
; Stone & Shiffman, 1994) was used to characterize and quantify a dynamic process--affective instability in
borderline personality disorder
(
BPD
). Sixty outpatients (34 with
BPD
and affective instability; 26 with current depressive disorder but not with
BPD
or affective instability) carried electronic diaries for approximately 1 month and were randomly prompted to rate their mood state up to 6 times a day. Results indicated that
BPD
patients (a) did not report significantly different mean levels of positive or negative affect; (b) displayed significantly more variability over time in their positive and negative affect scores; (c) demonstrated significantly more instability on successive scores (i.e., large changes) for hostility, fear, and sadness than did patients with depressive disorders; and (d) were more likely to report extreme changes across successive occasions (>or=90th percentile of change scores across participants) for hostility scores. Results illustrate different analytic approaches to quantifying variability and instability of affect based on intensive longitudinal data. Further, results suggest the promise of electronic diaries for collecting data from individuals in their natural environment for purposes of clinical research and assessment.
...
PMID:Affective instability: measuring a core feature of borderline personality disorder with ecological momentary assessment. 1872 16
Ecological momentary assessment (
EMA
; Stone & Shiffman, 1994) was utilized to examine affective instability (AI) in the daily lives of outpatients with
borderline personality disorder
(
BPD
;
n
=78) with and without posttraumatic stress disorder (PTSD). A psychiatric control group (
n
=50) composed of outpatients with major depressive disorder/dysthymia (MDD/DYS) was employed to compare across subgroups:
BPD
-only, BPD+PTSD, MDD/DYS-only, and MDD/DYS+PTSD. Compared to the
BPD
-only group, the BPD+PTSD group had significantly greater instability of fear and sadness, but did not significantly differ in instability of hostility or aggregate negative affect. This pattern of elevated instability of fear and sadness was not present-and, in fact, was reversed-in the MDD/DYS group. Results emphasize the importance of examining AI within the context of specific comorbidities and affect types. Treatment and research addressing AI in the context of
BPD
-PTSD comorbidity may benefit from a focus on fear and sadness as separate from hostility or general negative affect.
...
PMID:Negative Affect Instability among Individuals with Comorbid Borderline Personality Disorder and Posttraumatic Stress Disorder. 2690 88