Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0268318 (
ICP
)
10,007
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Intrahepatic cholestasis of pregnancy
(
ICP
) is a liver disorder occurred in pregnant women, and the mechanism for such disease is still unclear. The bioinformatics analysis of our previous study has revealed the abnormal expression of
endoplasmic reticulum protein 29
(
ERp29
) in placental tissue of
ICP
patients. In this study, the function of
ERp29
was further explored using in vitro model of
ICP
. The results showed that up-regulation of
ERp29
occurred in TCA (taurocholic acid)-treated human trophoblast HTR-8/SVeno cells, and
ERp29
inhibition reversed TCA toxicity via attenuating G2/M arrest and cell apoptosis. Mechanical study revealed
ERp29
inhibition suppressed phosphorylation and kinase activity of p38, thus subsequently affecting expression and phosphorylation of p53 (ser18) as well as the transcriptional activity of p53. The conduction of this study might confirm the important role of
ERp29
in
ICP
and which would be helpful for the development of target therapeutic method for
ICP
.
...
PMID:ERp29 inhibition attenuates TCA toxicity via affecting p38/p53- dependent pathway in human trophoblast HTR-8/SVeno cells. 3158 54
