Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0268318 (ICP)
 10,007 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 58 female patients with the primary empty sella (PES) syndrome, a study of the CSF dynamics was done by evaluating both the absorptive reserve by a lumbar infusion test at constant rate, and/or the ICP increase occurring during REM phase of nocturnal physiological sleep. In 33, prolactin (PRL) dynamics were also investigated evaluating both the response to sequential stimulating test with thyrotropin-releasing hormone (TRH) and metoclopramide (MCP) and/or the circadian variation of PRL levels. Impairment of CSF dynamics was found in the 84% who had a hormonal pattern characterized by an increase of the PRL response to TRH and MCP and a decrease of the PRL circadian variation. Twenty-one patients with impaired CSF dynamics underwent CSF shunting procedures with disappearance of the signs of intracranial hypertension. They also had restoration of normal PRL dynamics but the endocrine alterations improved only moderately. Altered CSF dynamics play a role in the pathogenesis of the PES syndrome. A correlation between elevated ICP and the hypothalamo-hypophyseal control of PRL secretion may exist.
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PMID:Cerebrospinal fluid pressure and prolactin in empty sella syndrome. 210 18

In order to describe variation in AP and ICP during OSA, six patients with severe OSA were examined, with determination of ICP, AP, CVP, respiration, tcPO2, tcPCO2, and nocturnal sleep polygraphy. During apnea, elevations of AP and ICP were observed, related to the apneic episodes. The elevations in pressure were only observed in relation to apneic episodes. While awake, none of the patients showed pressure elevations. There were highly significant correlations between duration of apnea and variation in AP and ICP and between variations in AP and ICP. Values for ICP while awake were above normal (greater than 15 mm Hg; intracranial hypertension) in four of six patients. Morning ICP was higher than evening ICP. Systolic, mean, and diastolic ICP and AP increased during sleep above awake values. The ICP increased during NREM stages 1 to 4, and the highest values were observed during REM sleep. Vascular response was not changed during REM sleep, and the higher ICP during REM could solely be explained by the longer apneas during REM sleep. The CPP decreased during apnea.
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PMID:Intracranial pressure and obstructive sleep apnea. 291 75

Nineteen hydrocephalic patients were studied to determine factors affecting cerebrospinal fluid (CSF) flow through shunts. This study was based on our previously reported method by which fluctuations in CSF flow through a shunt of from 0.01 ml min-1 to 1.93 ml min-1 were identified, each having its own rhythmic pattern. While CSF flow in a supine position was less than 0.01 ml min-1, head elevation to 60 degrees led to increases in CSF flow from 0.12 ml min-1 to 0.17 ml min-1. Sudden respiratory changes such as coughing also affected CSF flow. CSF flows were higher than average between 10 pm and 7 am, and changes in CSF flow were related to slight increases in ICP during REM sleep. There is no relationship between CSF flow in a shunt and daily fluid intake which varied from 27 ml kg-1 to 103 ml kg-1, and no significant changes in CSF flow resulting from rapid intravenous injection of Glycerol and Ringer's solution.
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PMID:Factors affecting cerebrospinal fluid flow in a shunt. 326 43

From the results of ICP determination in 6 cases of macrocrania, it is evident that Lundberg's pressure wave (plateau wave, B wave) can be sufficiently adapted for evaluating abnormality under the semi-closed circumference like infants. ICP determination in the case of macrocrania with mild enlarged ventricles important for knowing pathologic changes. In particular, pressure variation and amplitude changes during REM period seem to be an interesting index for knowing the involvement of venous function. The increased ICP during REM period was also observed in a patient with holoprosencephaly having brain stem formation only, suggesting an important relationship between brain stem and increased ICP during REM period.
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PMID:[Fontanelle pressure in infants (Part II). Discussion on 6 cases of macrocrania]. 402 52

ICP being a very significant parameter of intracranial pathology, it needs to be recorded continuously. ICP of 7 cases of normal pressure hydrocephalus (NPH) and 6 postoperative patients, for whom relationship between REM sleep and ICP was under discussion, was monitored at night and recorded by Brock's method. Polygraphic records also were obtained. Increased ICP was related to REM sleep in 3 of 6 postoperative cases. In the remaining 3 cases, REM sleep could not be observed the first postoperative night, and ICP was lower and stable all night. This fact may be an effect of anesthetic drugs. NPH patients were divided into 2 groups by pressure profile during night recording of ICP. One group of 2 cases demonstrated irregular ICP during REM sleep while the other group of 5 cases did not. The former 2 cases showed neurological improvement after shunt operations. In NPH cases, ICP has significance in deciding whether surgery is necessary. It appears reasonable to suggest that the augumentation of ICP during REM sleep in cases of hydrocephalus and postoperative condition is related to an increase in cerebral blood flow and an exhaustion of the absorptive mechanisms of CSF.
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PMID:[Intracranial pressure changes during sleep in man]. 668 71