Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0268318 (ICP)
 10,007 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Kojic acid-phenylalanine amide (KA-F-NH(2)), which showed an excellent tyrosinase inhibitory activity, did not inhibit melanogenesis in melanocyte due to its low cell permeability. To enhance its cell permeability by increasing lipophilicity, we prepared metal coordination compounds of KA-F-NH(2) and characterized them by FT-IR and ICP analysis. The metal complex of KA-F-NH(2) inhibited mushroom tyrosinase activity as much as KA-F-NH(2) and reduced melanin contents in melanocyte efficiently.
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PMID:Enhanced cell permeability of kojic acid-phenylalanine amide with metal complex. 1996 89

Cu-Kojic acid (KA) complex anchored to functionalized silica-MCM-41 was synthesized via the process of postgrafting and introduced as an effective, new, reusable, and thermally resistant heterogeneous nanocatalyst for the clean synthesis of 1H-1,2,3-triazoles from Click reaction of 2-(azidomethyl)-5-benzyloxy-4-pyrone and azido Kojic acid with a variety of terminal alkynes in excellent yields. The structure of nanocatalyst was analyzed by ICP, BET, XRD, EDS, SEM, TGA, TEM, and FT-IR techniques.
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PMID:Cu-Kojic Acid Complex Anchored to Functionalized Silica-MCM-41: A Promising Regioselective and Reusable Nanocatalyst for Click Reaction. 3292 68