Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0268318 (ICP)
 10,007 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 18 cases of perinatal intraventricular haemorrhage, continuous ventricular drainage was applied. As a result, ICP hypertension was inhibited and thus brain damage prevented. The early intervention prevented the formation of hydrocephalus (evoidence of shunt dependence) and aspiration of the bleeding prevented DIC and maintained coagulation factors.
 ...
PMID:Successful treatment of perinatal intraventricular haemorrhage. 54 18

Intrahepatic cholestasis of pregnancy is a relatively common disease. It has an unknown etiology and may have a recurrent pattern. It commonly occurs in the 2nd-3rd trimester and characteristically presents with pruritus, jaundice and abnormal liver function tests. There is also an increased risk of preterm delivery and of cesarean section. Both maternal and neonatal prognosis is generally good. We describe a case of intrahepatic cholestasis of pregnancy with an atypical presentation and outcome. Our patient presented with acute renal and hepatic failure with hepatic encephalopathy, DIC and hypertension which was the cause of the fetal death in the third trimester of the pregnancy.
 ...
PMID:[Intrahepatic cholestasis of pregnancy. A benign disease?]. 900 89

We have analysed 15 cases of jaundice type ICP (JICP). The result showed that the incidence of JICP was 12.7 percent in ICP patients while the rectified perinatal baby mortality was 12.7 percent in ICP patients while the rectified perinatal baby mortality was 26.7%. The main clinical features were early and severe jaundice. The average levels of the total bilirubin and direct bilirubin were 123.32 +/- 86.9 mumol.L-1 and 66.77 +/- 49.7 mumol.L-1, respectively. They were significantly higher than those of the common types (P < 0.01). The level of blood biliary acid increased obviously. The morbidity of JICP in the perinatal babies and postpartal hemorrhage in the mothers were increased. It is considered that: 1. The routine DIC examination should be taken and massive therapy of vitamin K should be given to these patients. 2. The proper delivery time is the 36-37th week gestation. 3. We should choose in principle the vaginal delivery in these patients. In the severe patients the elective caesarean section is the first choice and operative vaginal delivery is undesirable.
 ...
PMID:[Clinical analysis of 15 cases of jaundice type intrahepatic cholestasis in pregnancy (ICP)]. 1118 1

Internalization and subcellular localization in HeLa cells of gold nanoparticles modified with the SV40 large T antigen were quantified using inductively coupled plasma optical emission spectroscopy (ICP-OES). Internalization was monitored as a function of incubation time, temperature, nanoparticle diameter, and large T surface coverage. Increasing the amount of large T peptides per gold nanoparticle complex, by either increasing the coverage at constant nanoparticle diameter or by increasing the nanoparticle diameter at constant large T coverage, resulted in more cellular internalization. In addition, nuclear fractionation was performed to quantify nuclear localization of these complexes as a function of large T coverage. In contrast to our prior qualitative investigations of nuclear localization by video-enhanced color differential interference contrast microscopy (VEC-DIC), ICP-OES was able to detect nanoparticles inside fractionated cell nuclei. Although increasing the large T coverage was found to afford higher cell internalization and nuclear targeting, quantitative evaluation of cytotoxicity revealed that higher large T coverages also resulted in greater cytotoxicity. The ICP-OES and nuclear fractionation techniques reported here are valuable tools that can add important quantitative information to optical and electron imaging methods such as VEC-DIC and transmission electron microscopy regarding the fate of nanoparticles in cells.
 ...
PMID:Cellular uptake of gold nanoparticles passivated with BSA-SV40 large T antigen conjugates. 1797 1