Gene/Protein Disease Symptom Drug Enzyme Compound
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The transition metal complexes of Co(II), Ni(II), and Cu(II) derived from N'-((5-(2,5-dichlorophenyl)furan-2-yl)methylene)-2-hydroxybenzohydrazide (L24) and N'-((5-(2, 5-dichlorophenyl)furan-2-yl)methylene)benzohydrazide (L21) have been synthesized by conventional as well as microwave method being shorter time consuming, solvent less and gives improved yields as compared to the traditional conventional technique. These compounds were characterized by melting point, TLC, FTIR, 1H-NMR, elemental analysis, potentiometric titration, ICP-OES and EIMS. From this analytical data it is confirmed that complexes are in octahedral structure with coordination number 6 which revealed 1:2 (metal:ligand). FTIR data shows that these synthesized hydrazone ligands have ONO donor sites and coordinate with transition metal ions in a tridentate monobasic manner. All these synthesized compounds were tested for evaluation of antibacterial activity by agar disc diffusion assay and total antioxidant activity by Phosphomolybdenum method.
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PMID:Microwave and conventional synthesis of Co (II), Cu (II) and Ni (II) metal complexes of some acid hydrazones with their spectral characterization and biological evaluation. 2973 37