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In this study the growth curves of 229 children (145 boys, 84 girls ) with idiopathic short stature (ISS) were analysed in three ways: (1) we compared the results of longitudinal modelling by means of Karlberg's ICP model with those of a cross-sectional analysis; (2) we studied to what extent an individual changes his/her height standard deviation score (SDS) position during childhood; and (3) we constructed height velocity curves for children with ISS using Cole's LMS method, and compared these with the British references. During childhood the difference between the average longitudinal and the cross-sectional height curves was less than 1 cm and the spread was almost identical. The average change in height SDS during childhood was not different from zero, indicating that in general growth of children with ISS was well canalized. The individual change in height SDS position during childhood was within 0.6 SDS for a follow-up of 1 year, increasing to 1.9 SDS for a follow-up of 7 years. During childhood mean height velocity was about 1 cm/year lower than that of the British reference. With respect to the pubertal growth spurt the maximum height velocity took place 1 year later, and was 0.6 cm/year lower than the British reference in boys as well as girls. We conclude that spontaneous growth of children with ISS adequately described by a cross-sectional curve.
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PMID:Longitudinal analysis of growth in children with idiopathic short stature. 939 42

Direct quantitative and sensitive chemical analysis of solid materials with high spatial resolution, both in lateral and vertical direction is of high importance in various fields of analytical research, ranging from in situ space research to the semiconductor industry. Accurate knowledge of the chemical composition of solid materials allows a better understanding of physical and chemical processes that formed/altered the material and allows e.g. to further improve these processes. So far, state-of-the-art techniques such as SIMS, LA-ICP-MS or GD-MS have been applied for chemical analyses in these fields of research. In this report we review the current measurement capability and the applicability of our Laser Ablation/Ionisation Mass Spectrometer (instrument name LMS) for the chemical analysis of solids with high spatial resolution. The most recent chemical analyses conducted on various solid materials, including e.g. alloys, fossils and meteorites are discussed.
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PMID:Laser Ablation/Ionisation Mass Spectrometry: Sensitive and Quantitative Chemical Depth Profiling of Solid Materials. 2713 Nov 12