Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0268318 (ICP)
 10,007 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Polygraphic studies were performed over periods of 14 to 76 hours in 30 patients with reccent closed cranial injuries. Correlations between ICP and EEG findings were rarely found (3/16) in cases of cerebral dysfunction of mesodiencephalic or lower levels, where both ICP and EEG were usually stable. Correlations are regularly found in diencephalic or higher (10/14) levels and their presence is of favourable prognostic significance. Generally, delta waves at 1,5-2 cs, high in amplitude (type A) accompany reduced or low ICP levels,while a rapid and low voltage tracing (type B) is associated with raised or high levels of ICP. In the latter cases, a very slow (0.5 cs) and low in amplitude tracing (type C) can progressively replace the type B. The classical periodic or alternating tracing associates alternate sequences of type A and B and is observed simultaneously with type B pressure waves. These correlations are analogous with those observed during the evolution of intracranial tumors or hydrocephalus. The EEG modifications are probably related more to the pathological lesion than to a direct action of fluctuations in ICP.
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PMID:[Correlations between intracranial pressure variations and EEG changes in patients with cranial trauma (author's transl)]. 53 24

26 patients with intracranial tumors on the stage of severe clinical decompensation were treated in S.P. Botkin Municipal Hospital from 2005 till 2010. The main group (18 cases) included patients who underwent urgent neurosurgical procedures due to decompensation. This group was evaluated prospectively. Control group (8 cases) consisted of patients who received only conservative treatment. Application of this therapeutic tactics allowed decrease of mortality from 100% after palliative conservative treatment to 11% (2 cases) after aggressive surgical management shortly after deterioration. Condition of patients was assessed using GCS. Outcomes were evaluated by GOS. Mean preoperative GCS score was 5.3 in the surgical group. In control group this value was 4. Mean postoperative GOS score was 3.9. In control group mortality reached 100%. Perioperative ICP monitoring demonstrated severe intracranial hypertension in all cases. Analysis showed that urgent decompressive procedure in decompensated patients with intracranial tumors is treatment of choice if antiedematous treatment is ineffective. If no positive dynamics in neurological symptoms is observed, neurosurgeon should immediately perform wide external and internal decompression with duraplasty. Decision about urgent operation is strictly individual and should be based on size and localization of the tumor, concominant diseases, duration of coma and stability of haemodynamics.
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PMID:[Urgent neurosurgical operations in neurooncology]. 2206 58