Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0268318 (ICP)
 10,007 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnosis of hemangioblastoma in the posterior cranial fossa was confirmed in 56 patients operatively and pathologically. The tumors were cystic in 44 patients and solid in 12; 87.5% of the tumors occurred in the cerebellar hemisphere and 7.1% in the vermis. The main symptoms and signs were increased ICP and cerebellar incoordination. 64 surgical operations had been performed in the 56 patients. Seven patients died and 8 (14%) had recurrence postoperatively. The effect of surgical intervention in 40 patients with cystic hemangioblastoma was satisfactory. Among 5 patients with solid tumor, 2 recovered completely and 3 still had partial neurological disability.
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PMID:[Hemangioblastoma in posterior cranial fossa. Report of 56 cases]. 181 64

A case of a brain stem hemangioblastoma with recurrent episodes of hypacusis due to progression of hydrocephalus is reported. The patient was a 25-year-old female, admitted to the department of otorhinolaryngology with complaints of hearing difficulty, headache and blurred vision. Neuroradiological studies showed a tumor from the medulla oblongata, obliterating the IVth ventricle, and a secondary hydrocephalus. Hearing loss fluctuated as hydrocephalus progressed. Multiple V-P shunting procedures relieved episodic hypacusis. The patient remains asymptomatic at present and has resumed normal activity. The mechanism of episodic hearing loss due to hydrocephalus is though to be due to the fact that through the ductus perilymphaticus and the ductus endolymphaticus, especially the former, increased intracranial pressure is transmitted to the inner ear. Through the ductus perilymphaticus there is communication between the perilymphatic space and the intracranial subarachnoid space. Through the ductus endolymphaticus there is communication with the subdural space. Increased ICP effects the inner ear. It is suspected that, in this particular case, the progression of hydrocephalus effected the patient's hearing.
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PMID:[A case of hydrocephalus with hypacusis due to hemangioblastoma]. 204 55