Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0267964 (PAA)
 2,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Molar partition coefficients for amphiphilic N-[2-(2-alkyl-oxyphenyl-carbamoyloxy)-ethyl]-piperidinium chlorides (PAA) between small unilamellar egg yolk phosphatidyl choline liposomes and saline, as determined by ultraviolet difference spectroscopy at 22 degrees C, pH 5-6, v = 34640 cm-1, and at 100 mumol/l PAA concentration, were 149, 1990, and 7474 for PAA with 5, 7, and 9 carbon atoms in the alkyloxy substituent, respectively. At the PAA concentration used, the cut-off in biological activities of PAAs with long alkyloxy substituents could not be caused by the self-association of PAA molecules in the aqueous phase.
Gen Physiol Biophys 1992 Jun
PMID:Partition of piperidinoethylesters of 2-alkyloxyphenylcarbamic acid in unilamellar phosphatidylcholine liposomes. 142 76

By comparative sequence analysis of the herpes simplex virus type 1 DNA polymerase gene of strain Angelotti and a phosphonoacetic acid-resistant (PAAr) derivative, the site of the PAAr mutation was identified as a single nucleotide (C----T) conversion within the mapping limits of the known PAAr mutations of strains KOS and 17. The conservative amino acid change at residue 719 from alanine to valine results in a radical change in the properties of the polymerase, rendering the mutant enzyme resistant to PAA and various antiviral compounds. Amino acid homologies as well as secondary structure analysis reveal that the PAAr mutation is contained in a 14 amino acid sequence which is highly conserved, and detected in the central domain of prokaryotic and eukaryotic DNA polymerases.
J Gen Virol 1987 May
PMID:The herpes simplex virus type 1 DNA polymerase gene: site of phosphonoacetic acid resistance mutation in strain Angelotti is highly conserved. 303 42

1. Rabbit serum was shown to contain two cholinesterases which hydrolysed acetylthiocholine and butyrylthiocholine and one cholinesterase which hydrolysed only butyrylthiocholine. 2. The three enzymes were identified by the kinetics of heat inactivation and kinetics of phosphorylation by the organophosphate VX. 3. Using selective inhibitors (iso-OMPA, eserine, BNPP and BW-284C51) it was shown that the hydrolysis of acetylthiocholine and butyrylthiocholine in untreated native serum had properties of acetylcholinesterase (EC 3.1.1.7), butyrylcholinesterase (EC 3.1.1.8) and also some properties of carboxylesterase (EC 3.1.1.1). 4. Separation of proteins (on PAA-gels) in untreated native serum gave four bands with acetylthiocholine and three with butyrylthiocholine. 5. The two cholinesterases hydrolysing both substrates corresponded to the slow moving bands on the gel. 6. The fastest moving band hydrolysing only butyrylthiocholine could be attributed to the cholinesterase least sensitive to VX.
Gen Pharmacol 1988
PMID:Cholinesterases in rabbit serum. 322 26

Consultation rates, visiting rates and a selection of miscellaneous services were recorded over two weeks in February 1981 by 82 doctors in Bedfordshire and Hertfordshire. The findings are reported here with an emphasis on the variation between individual doctors. Consultations (including visits) were at the rate of 3.27 per patient per year. Undertaking a selection of miscellaneous services for patients is estimated to be equivalent to one third of the doctor's consultation workload. In addition, participating doctors spent an average of 9(1/2) hours in the two weeks undertaking tasks connected with education and health service administration. Time spent in the administration and management of the practice was not included in this study.The home visiting rate reported in this study was 14 per cent of all consultations and, although a little lower than that reported in the General Household Survey, it is similar to the results from the National Morbidity Survey for 1970 and 71 and also similar to other PAA results.The material is presented in such a way that it provides an analysis of workload in a large number of practices, and describes a method which doctors can use to measure their own performance and compare it with the overall results.
J R Coll Gen Pract 1982 May
PMID:Workload review. Birmingham Research Unit, Royal College of General Practitioners. 710 54