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Target Concepts:
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Query: UMLS:C0267964 (
PAA
)
2,561
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Zinc can enhance osteoblastic bone formation and stimulate osteogenic differentiation, suppress the differentiation of osteoclast precursor cells into osteoclasts, and inhibit pathogenic bacterial growth in a dose-dependent manner. In this study, simonkolleite, as a novel zinc resource, was coated on poly (amino acids) (
PAA
) via suspending
PAA
powder in different concentrations of zinc chloride (ZnCl
2
) solution, and the simonkolleite-coated
PAA
(Zn-
PAA
) was characterized by SEM, XRD, FT-IR and XPS. Zinc ions were continuously released from the coating, and the release behavior was dependent on both the concentration of the ZnCl
2
immersing solution and the type of soak solutions (
SBF
, PBS and DMEM). The Zn-
PAA
was cultured with mouse bone marrow stem cells (BMSCs) through Transwell
TM
plates, and the results indicated that the relative cell viability, alkaline phosphatase (ALP) activity and mineralization of BMSCs were significantly higher with Zn-
PAA
as compared to
PAA
. Moreover, the Zn-
PAA
was cultured with RAW264.7 cells, and the results suggested an inhibiting effect of Zn-
PAA
on the cell differentiation into osteoclasts. In addition, Zn-
PAA
exhibited an antibacterial activity against both
S. aureus
and
E. coli
. These findings suggest that simonkolleite coating with certain contents could promote osteogenesis, suppress osteoclast formation and inhibit bacteria, indicating a novel way of enhancing the functionality of synthetic bone graft material and identifying the underline principles for designing zinc-containing bone grafts.
...
PMID:Simonkolleite Coating on Poly(Amino Acids) to Improve Osteogenesis and Suppress Osteoclast Formation in Vitro. 3152 42
Novel phosphonic acid-functionalized poly(amido amine) (
PAA
) macromers are synthesized through aza-Michael addition of 2-aminoethyl phosphonic acid or its mixture with 5-amino-1-pentanol at different ratios onto N,N'-methylene bis(acrylamide) to control the amount of phosphonic acid functionality. The macromers were homo- and copolymerized with 2-hydroxyethyl methacrylate at different ratios to obtain hydrogels with various hydrophilicities. The hydrogels' swelling, biodegradation and mineralization properties were evaluated. The swelling and degradation rates of the gels can be tuned by the chemical structure of
PAA
macromer precursors as well as pH and CaCl
2
pre-treatment. The hydrogels show composition-dependent mineralization in
SBF
and 5xSBF, as evidenced from Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX) analyses. The degradation products of the hydrogels have no effect on U-2 OS, Saos-2 and NIH 3T3 cells, suggesting their cytocompatibility. Overall, these materials have potential to be used as nontoxic degradable biomaterials.
...
PMID:Phosphonic acid-functionalized poly(amido amine) macromers for biomedical applications. 3231 10
