Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0267964 (PAA)
 2,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Based on the premise that similar surface properties between the adhesive and the substrate would yield a strong adhesive bond, copolymers of acrylic acid (AA) and 2-ethylhexyl acrylate (EHA), P(AA-co-EHA), were designed and synthesized for buccal mucoadhesion. A series of linear copolymers with varying feed ratios of the two monomers (AA and EHA) were synthesized through free radical copolymerization at 69+/-0.5 degrees C using azobis(isobutyronitrile) (AIBN) as initiator. The reactions were carried out in THF under nitrogen for 24 h. The glass transition temperatures, T(g), of the copolymers were determined using DSC. The adhesion studies were conducted to determine the effects of copolymer composition, contact time between the substrate and the adhesive, and crosshead speed on mucoadhesive performance of the copolymer films using a computer interfaced Instron material testing system. The glass transition temperature of the copolymers decreased with increasing EHA content. Wet glass surface as substrate was shown not to be a good substrate model for adhesion determination studies. The copolymer composed of 46:54 mol.% AA:EHA (an almost 1:1 ratio in the repeat units) yielded the highest mucoadhesive force in contact with porcine buccal mucosa which was significantly greater (P<0.05) than that of poly(acrylic acid) (PAA) (used as positive control). The mucoadhesive force for all copolymers studied was significantly (P<0.05) greater than that of the negative control (backing material without copolymer film) except for the EHA homopolymer. Crosshead speed increased mucoadhesive force linearly and had a more pronounced effect on the mucoadhesive performance than time of contact between the adhesive and the substrate.
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PMID:Evaluation of poly(acrylic acid-co-ethylhexyl acrylate) films for mucoadhesive transbuccal drug delivery: factors affecting the force of mucoadhesion. 1082 56

This investigation aimed to derive alternative guidelines for syphilis. In the first step of this study monodisperse PGMA particles were synthesised by dispersion polymerization of the GMA monomer by using AIBN as initiator and PAA as stabilizator. A series of characterization experiments were done. In the second step of the study the characterized particles were used as microcarriers for the immobilization of the natural antigen for the purpose of diagnosing syphilis. The covalent binding method was used and GA was utilized as a spacer arm. The optimum immobilization conditions for the binding of natural antigen onto the particles were determined. In the third and the last step of the study the agglutination tests were realized with in vitro experiments by using both serum samples taken from syphilis patients and positive controls. After these experiments the kits chosen among the ones showing high performance were compared with the commercial RPR kit being used widely by reacting with serially diluted positive controls and patient serums. After this comparison the performances of the synthesized kits were found as satisfactory as the commercial kits.
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PMID:Synthesis of diagnostic test kits for syphilis with polymeric particles. 1600 19