Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0267964 (
PAA
)
2,561
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Energy transfer between a CdSe/ZnS nanocrystal (NC) donor and a rhodamine isothiocyanate (RITC) acceptor has been achieved via a functionalized poly(acrylic acid) (
PAA
) encapsulating layer over the surface of the NC. The modification of
PAA
with both
N
-octylamine (OA) and 5-amino-
1-pentanol
(AP), [
PAA
-OA-AP], allows for the simultaneous water-solubilization and functionalization of the NCs, underscoring the ease of synthesizing NC-acceptor conjugates with this strategy. Photophysical studies of the NC-RITC constructs showed that energy transfer is efficient, with
k
FRET
approaching 10
8
s
-1
. The ease of the covalent conjugation of molecules to NCs with
PAA
-OA-AP coating, together with efficient energy transfer, makes the NCs encapsulated with
PAA
-OA-AP attractive candidates for sensing applications.
...
PMID:Energy Transfer of CdSe/ZnS Nanocrystals Encapsulated with Rhodamine-Dye Functionalized Poly(acrylic acid). 2492 75
Novel phosphonic acid-functionalized poly(amido amine) (
PAA
) macromers are synthesized through aza-Michael addition of 2-aminoethyl phosphonic acid or its mixture with 5-amino-
1-pentanol
at different ratios onto N,N'-methylene bis(acrylamide) to control the amount of phosphonic acid functionality. The macromers were homo- and copolymerized with 2-hydroxyethyl methacrylate at different ratios to obtain hydrogels with various hydrophilicities. The hydrogels' swelling, biodegradation and mineralization properties were evaluated. The swelling and degradation rates of the gels can be tuned by the chemical structure of
PAA
macromer precursors as well as pH and CaCl
2
pre-treatment. The hydrogels show composition-dependent mineralization in SBF and 5xSBF, as evidenced from Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX) analyses. The degradation products of the hydrogels have no effect on U-2 OS, Saos-2 and NIH 3T3 cells, suggesting their cytocompatibility. Overall, these materials have potential to be used as nontoxic degradable biomaterials.
...
PMID:Phosphonic acid-functionalized poly(amido amine) macromers for biomedical applications. 3231 10
