Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0267964 (
PAA
)
2,561
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The cytological location of ion channel antagonist-binding sites was studied in sunflower protoplasts using the fluorescent probes DM-Bodipy-
PAA
and DM-Bodipy-DHP. The binding specificity of the probes was established by competition experiments with
Bepridil
, phenylalkylamine (Verapamil) and dihydropyridine (Nifedipine) which are known as calcium and potassium channel antagonists. Quantitative image analysis of the fluorescence emitted by the protoplasts showed the existence of interactions between
PAA
- and DHP-binding sites. Moreover, studies on the cytolocalization of the
PAA
receptors by confocal imaging showed that in freshly isolated protoplasts, DM-Bodipy-
PAA
binds exclusively at sites located in the cortical region of the cell.
...
PMID:Studies on ion channel antagonist-binding sites in sunflower protoplasts. 924 54
