Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0267964 (PAA)
 2,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ultrathin fibers comprising 2-weak polyelectrolytes, poly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) were fabricated using the electrospinning technique. Methylene blue (MB) was used as a model drug to evaluate the potential application of the fibers for drug delivery. The release of MB was controlled in a nonbuffered medium by changing the pH of the solution. The sustained release of MB in a phosphate buffered saline (PBS) solution was achieved by constructing perfluorosilane networks on the fiber surfaces as capping layers. Temperature controlled release of MB was obtained by depositing temperature sensitive PAA/poly(N-isopropylacrylamide) (PNIPAAM) multilayers onto the fiber surfaces. The controlled release of drugs from electrospun fibers have potential applications as drug carriers in biomedical science.
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PMID:Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties. 1741 41

Humic acid-immobilized amine modified polyacrylamide/bentonite composite (HA-Am-PAA-B) was prepared and used as an adsorbent for the adsorption of cationic dyes (Malachite Green (MG), Methylene Blue (MB) and Crystal Violet (CV)) from aqueous solutions. The polyacrylamide/bentonite composite (PAA-B) was prepared by intercalative polymerization of acrylamide with Na-bentonite in the presence of N,N'-methylenebisacrylamide as a crosslinking agent and hexamethylenediammine as propagater. PAA-B was subsequently treated with ethylenediammine to increase its loading capacity for HA. The surface characterizations of the adsorbent were investigated. The adsorbent behaved like a cation exchanger and more than 99.0% removal of dyes was detected at pH range 6.0-8.0. The capacity of HA-Am-PAA-B was found to decrease in the following order: MG > MB > CV. The kinetic and isotherm data were interpreted by pseudo-second order rate equation and Freundlich isotherm model, respectively. Experiments were carried out using binary solute systems to assess the competitive adsorption phenomenon. The experimental isotherm data for each binary solute combination of MG, MB and CV were analyzed using Sheindrof-Rebhun-Sheintuch (SRS) (multicomponent Freundlich type) equation.
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PMID:Adsorption characteristics of humic acid-immobilized amine modified polyacrylamide/bentonite composite for cationic dyes in aqueous solutions. 1986 52

The Methylene Blue loaded Polyacrylamide Nanoparticles (MB-PAA NPs) are used for oxygen sensing and Photodynamic therapy (PDT), a promising therapeutic modality employed for various tumors, with distinct advantages of delivery of biomedical agents and protection from other bio-molecules overcoming inherent limitations of molecular dyes. Lifetime-resolved photoacoustic spectroscopy using quenched-phosphorescence method is applied with MB-PAA NPs so as to sense oxygen, while the same light source is used for PDT. The dye is excited by absorbing 650 nm wavelength light from a pump laser to reach triplet state. The probe laser at 810 nm wavelength is used to excite the first triplet state at certain delayed time to measure the dye lifetime which indicates oxygen concentration. The 9L cells (106 cells/ml) incubated with MB-PAA NP solution are used for monitoring oxygen level change during PDT in situ test. The oxygen level and PDT efficacy are confirmed with a commercial oximeter, and fluorescence microscope imaging and flow cytometry results. This technique with the MB-PAA NPs allowed us to demonstrate a potential non-invasive theragnostic operation, by monitoring oxygen depletion during PDT in situ, without the addition of secondary probes. Here, we demonstrate this theragnostic operation, in vitro, performing PDT while monitoring oxygen depletion. We also show the correlation between O2 depletion and cell death.
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PMID:Lifetime-resolved Photoacoustic (LPA) Spectroscopy for monitoring Oxygen change and Photodynamic Therapy (PDT). 2852 2

Electrospun polyacrylonitrile fiber membranes (EPFMs) were coated with multilayer films, assembled using the layer-by-layer (LbL) technique through the alternate deposition of poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA), to develop an antithrombogenic drug release membrane for hemodialysis. Methylene blue (MB) and heparin (HEP) were attached to the PAH and PAA multilayers, respectively, as model drug and antithrombogenic agent to investigate the dual functionality of the membranes. The positively (PAH, MB) and negatively (PAA, HEP) charged groups generated a supermolecular polyelectrolyte multilayer film (SPF) capable of loading high amounts of MB and HEP on the EPFMs at appropriate composition. The pH was fixed at 5.5 during assembly to stabilize the SPF. Heavy assembly of the PAH/PAA multilayer occurred at 10 wt% of both MB and HEP with 25 cycles of LbL deposition, and it exhibited long-term release of MB and low release of HEP at pH 7.4 in a circulatory system. The SPF-coated EPFMs also achieved low platelet attachment after 4 h of platelet rich plasma circulation and showed prolonged clotting times including thromboplastin, thrombin, and prothrombin times. Collectively, these observations suggest that SPF-coated EPFMs have great potential for use as hemodialysis membranes with positively charged drug loading.
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PMID:Preparation of biofiltration membranes by coating electrospun polyacrylonitrile fiber membranes with layer-by-layer supermolecular polyelectrolyte films. 3219 74