Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0267964 (
PAA
)
2,561
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The cytological location of ion channel antagonist-binding sites was studied in sunflower protoplasts using the fluorescent probes DM-Bodipy-
PAA
and DM-Bodipy-DHP. The binding specificity of the probes was established by competition experiments with Bepridil, phenylalkylamine (
Verapamil
) and dihydropyridine (Nifedipine) which are known as calcium and potassium channel antagonists. Quantitative image analysis of the fluorescence emitted by the protoplasts showed the existence of interactions between
PAA
- and DHP-binding sites. Moreover, studies on the cytolocalization of the
PAA
receptors by confocal imaging showed that in freshly isolated protoplasts, DM-Bodipy-
PAA
binds exclusively at sites located in the cortical region of the cell.
...
PMID:Studies on ion channel antagonist-binding sites in sunflower protoplasts. 924 54
