Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0267964 (
PAA
)
2,561
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The reduced susceptibility of biofilm to disinfectants presents a challenge to the successful reprocessing of medical equipment. This study examined the effect of residual biomass remaining after previous
PAA
disinfection on tolerance of subsequent mature P. aeruginosa biofilms to
PAA
. The effect of enzymatic degradation of specific components of P. aeruginosa biofilm
EPS
on the effectiveness of
PAA
disinfection was also evaluated. The presence of residual biomass from previously disinfected biofilms significantly enhanced the tolerance of a subsequent biofilms. A 96hr old "secondary biofilm" formed on disinfected biomass survived
PAA
concentrations of 4000 ppm, which exceeds the concentrations used in practice for high-level disinfection. These observations indicate that, under certain circumstances recolonisation of residual
EPS
can cause failure of disinfection of medical equipment such as endoscopes and emphasises the importance of cleaning of endoscopes prior to disinfection.
...
PMID:"Secondary biofilms" could cause failure of peracetic acid high-level disinfection of endoscopes. 3309 59
