Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0267964 (PAA)
 2,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author present a review of contemporary views on the pathogenesis of type I diabetes, in particular with regard to recent research of European and non-European diabetelogical departments. In the aetiopathogenesis attention is drawn to genetic influences, external factor and stimuli, the importance of some virus groups (Picornidae, Mengo 2T virus, Coxsackie B5, cytomegaloviruses, congenital rubeola syndrome etc.). Special attention is paid to the autoimmune theory of type I diabetes, the importance of different types of anti- beta-cell antibodies, insulin antibodies, antibodies against protein 64-KD of the islets, pro-insulin antibody PAA, and other stimuli and interferences (oxidation stress, non-enzymatic glycosylation etc.). As to treatment, the author mentions immunosuppressive treatment (cyclosporin A, azathioprine, prednisone) and transplantation of the pancreas. The author presents his own experience with a group of 2040 diabetics; in a group of 253 juvenile diabetics he followed-up the development of micro- and macroangiopathic complications in the course of 25 years. He proved an increase of so-called late diabetic complications in particular vascular ones along with the lengthening period of diabetes, with advancing age during its clinical manifestation. In the conclusion the author draws attention to the importance of multi-centre studies and new laboratory techniques.
 ...
PMID:[New findings in type I diabetes]. 813 Nov 77

Interaction of polystirolsulphonate with polymerization degree of 8 (PSS-8) and polyallylamin PAA (molecular mass 60 kilodaltons) with viruses from bloodline of paramixo- and orthomixoviruses by the example of measles virus, parotitis and flu leads to the decreasing of infective activity. The possible mechanism of viral inhibitive action of these chemical compounds is damaging of interfacial antigenic proteins of paramixo- and orthomixoviruses. In this study it was detected the change of surface tension of bilayer lipid membrane in the presence of PSS-8 and PAA. The change of surface tension leads to disorder in viral proteins adsorption in bilayer lipid membrane. This process could lead to disorder of juncture and self-assembly of virions.
 ...
PMID:[Study of interaction of polystirolsulphonate with polymerization degree of 8 and polyallylamin with bilayer lipids membranes]. 2259 83