Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0267964 (PAA)
 2,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A UV pre-irradiation step followed by a UV grafting step was used to graft poly(acrylic acid) (PAA) on polymeric substrates. These substrates were then used to investigate the influence of carboxyl groups (-COOH) on cell behavior. Both the attachment and differentiation behaviors of C17.2 cells showed a -COOH group density-dependent response. In order to achieve an even distribution of cells on a -COOH gradient surface for neuron differentiation studies, an Ar plasma post-treatment was applied to the PAA-grafted surfaces. It greatly improved the cell adhesion properties with little damage to -COOH groups. This allows uniform distributions of seeded cells even on substrates with -COOH gradients. A linear or stepped -COOH gradient was found to be capable of serving as a repelling cue to guide the outgrowth of neurites from C17.2 cells. Up to 3.7 times more cells developed neurites growing down the -COOH gradient than growing up it.
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PMID:Influence of carboxyl group density on neuron cell attachment and differentiation behavior: gradient-guided neurite outgrowth. 1576 31