Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0265264 (
HOS
)
1,119
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
AT-rich interactive domain-containing protein 1A
(
ARID1A
) has been shown to function as a tumour suppressor in various malignancies. However, the biological role of
ARID1A
in osteosarcoma is not clear. The present study aimed to investigate the expression pattern, prognostic value and the biological role of
ARID1A
in human osteosarcoma.
ARID1A
expression in 53 osteosarcoma surgical specimens was examined by quantitative real-time polymerase chain reaction, and its clinical significance was analysed. The role of
ARID1A
in cell proliferation, apoptosis, and metastasis were examined.
ARID1A
mRNA expression were significantly down-regulated in osteosarcoma tumours from that in matched adjacent non-tumour tissues.
ARID1A
expression was significantly inversely correlated with tumour stage and distant metastasis, as well as poor overall survival in patients with osteosarcoma. Furthermore,
ARID1A
mRNA was down-regulated in four human osteosarcoma cell lines MG-63, U2OS,
HOS
and Saos-2. Restoring of
ARID1A
expression in MG-63 and U2OS cells significantly inhibited cell proliferation and metastasis in vitro. Collectively, our data demonstrate that
ARID1A
may serve as a tumour suppressor in osteosarcoma progression, and represent a valuable prognostic marker and potential therapeutic target for osteosarcoma.
...
PMID:Low Arid1a Expression Correlates with Poor Prognosis and Promotes Cell Proliferation and Metastasis in Osteosarcoma. 2917 69
