Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0265264 (
HOS
)
1,119
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The use of protonated N-heterocyclic compound, i.e. 2,2'-bipyridinium cation, [bpyH
+
], enabled to obtain the new nitrilotriacetate oxidovanadium(IV) salt of the stoichiometry [bpyH][VO(nta)(H
2
O)]H
2
O. The X-ray measurements have revealed that the compound comprises the discrete mononuclear [VO(nta)(H
2
O)]
-
coordination ion that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The antitumor activity of [bpyH][VO(nta)(H
2
O)]H
2
O and its phenanthroline analogue, [phenH][VO(nta)(H
2
O)](H
2
O)
0.5
, towards human osteosarcoma cell lines (MG-63 and
HOS
) has been assessed (the
LDH
and BrdU tests) and referred to cis-Pt(NH
3
)
2
Cl
2
(used as a positive control). The compounds exert a stronger cytotoxic effect on MG-63 and
HOS
cells than in untransformed human osteoblast cell line. Thus, the [VO(nta)(H
2
O)]
-
containing coordination compounds can be considered as possible antitumor agents in the osteosarcoma model of bone-related cells in culture.
...
PMID:Characterization and cytotoxic effect of aqua-(2,2',2''-nitrilotriacetato)-oxo-vanadium salts on human osteosarcoma cells. 2820 78
