Gene/Protein
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Compound
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Target Concepts:
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Query: UMLS:C0265264 (
HOS
)
1,119
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BetaTrCP and
HOS
are closely related F-box proteins, which play key roles in ubiquitination and degradation of beta-catenin and IkappaB through associating with those phosphorylated substrates and recruiting SCF E3 ubiquitin ligase. Here we report that activation of Wnt/beta-catenin signal transduction pathway elevates
betaTrCP
levels but inhibits expression of
HOS
in 293T cells. Similar disparity is likely to exist in human colorectal tumors. In the NIH3T3 cells, which express
HOS
, but not
betaTrCP
, Wnt/beta-catenin signaling leads to inhibition of
HOS
promoter activity and NF-kappaB-driven transcription as well as to stabilization of beta-catenin. These results indicate that expression and activities of
HOS
are negatively regulated by Wnt/beta-catenin pathway.
...
PMID:Inhibition of HOS expression and activities by Wnt pathway. 1185 Aug 14
