Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0264733 (ventricular dilatation)
 2,163 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Newly hatched male White Pekin ducklings (n = 119) were allotted to 7 groups of 17 each and fed furazolidone (FZ) at dose levels of 0, 100, 250, 500, 750, 1,000, and 1,250 mg/kg of feed for 4 weeks. The frequency and severity of clinical signs of FZ toxicosis, including growth retardation, ascites, and mortality, were dose related. At necropsy, the affected ducklings had ascites, hydropericardium, and biventricular dilatation. The frequencies of cardiomyopathy, ascites, and mortality, respectively, for the several dose levels of drug were as follows: 0, 100, and 250 mg of FZ/kg of feed--0%, 0%, 0%; for the 500 mg/kg level--35%, 12%, 0%; for the 750 mg/kg level--100%, 53%, 18%; for the 1,000 mg/level--79%, 57%, 57%; and for the 1,250 mg/kg level--33%, 20%, 73%. Ducklings with FZ-induced congestive cardiomyopathy had decreased left ventricular free wall and ventricular septal thickness, increased left ventricular chamber diameter, increased left ventricular dilatation score, decreased absolute heart weight, and increased relative heart weight. Cardiac histopathologic changes were minimal; some ducklings had myocytolysis. Liver and lungs were congested. Furazolidone-induced cardiomyopathy in ducklings offers a model for studies of congestive cardiomyopathy in a species that is free from the hereditary cardiomyopathy ("round heart disease") seen in turkeys.
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PMID:Congestive cardiomyopathy induced in ducklings fed graded amounts of furazolidone. 682 29

Newly hatched male White Pekin ducklings (n = 92) were allotted to 2 groups of 46 each and fed 750 mg of furazolidone (FZ)/kg of feed either for 8 weeks (group 1) or for 4 weeks followed by 4 weeks of no FZ intake (group 2). Regression of FZ-induced toxicosis was observed in ducklings of group 2 after cessation of FZ consumption, as evidenced by decreased mortality, progressive decrease in ascites, and increases in body weight gains. Necropsy of 8-week survivors revealed decreased frequency and severity of ascites in ducklings of group 2. The severity of FZ-induced cardiac alterations also was diminished, with a decrease in left ventricular dilatation score and an increase in absolute heart weights in 8-week survivors in group 2. Further evidence of regression of FZ-induced congestive cardiomyopathy after cessation of FZ ingestion was gained from development of intermediate cardiac damage severity scores and frequency and severity of ascites at necropsy in ducklings (previously studied) examined after 4 weeks of FZ feeding, compared with those found in group 1 (FZ 8 weeks) or in group 2 (FZ 4 weeks, no FZ 4 weeks) of the present study. Furazolidone-induced cardiac disease in ducklings offers an attractive model for studies of the pathogenesis of congestive cardiomyopathy and cardiac failure.
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PMID:Furazolidone-induced congestive cardiomyopathy in ducklings: regression of cardiac lesions after cessation of furazolidone ingestion. 687 4

Broiler chicks in different groups were fed furazolidone (0, 400 and 800 mg/kg feed) and sodium chloride (500 and 1510 mg/kg feed) separately and concurrently from 1 to 30 days of age. Furazolidone (Fz) induced ascites, leg weakness, convulsions, depression and mortality was exacerbated by concurrent feeding of 1510 mg NaCl. Hemorrhages in the liver, swollen kidneys, pallor of the kidneys and cystic testes were present in all birds fed furazolidone either alone or in combination with NaCl. However, at microscopic level, necrotic changes were observed in the liver and kidneys of birds fed NaCl only. Fz-induced cardiac ventricular dilatation and thinning of walls were more severe when 400 mg Fz was fed concurrently with 1510 mg NaCl but feeding of 800 mg Fz with the same level of NaCl resulted in partial amelioration of cardiac changes. It is suggested that high dietary NaCl may exacerbate and alter the clinical and morphological picture of Fz toxicosis.
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PMID:Effect of concurrent feeding of furazolidone and sodium chloride upon some clinical, pathological and cardiac morphometric parameters in broiler chicks. 859 92