Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0264733 (ventricular dilatation)
 2,163 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lumber subarachnoid pressure was monitored via intrathecally introduced catheter in 9 patients, who showed ventricular dilatation on brain CT and were suspected of normal pressure hydrocephalus. During the pressure measurement, 500 mg of acetazolamide was rapidly injected intravenously and changes of CSF pressure were recorded. The results of the study were compared to clinical signs, brain CT findings and results of continuous pressure monitoring. The types of response of CSF pressure induced by acetazolamide administration were classified into 2 groups. In 5 cases (Group A), more than 50 percent increase of CSF pressure compared to the resting value was noted. On the contrary, in the remaining 4 cases (Group B), CSF pressure showed only slight increase (less than 25 percent or none). VP shunt was performed in 4 cases in Group A. Definite improvement of clinical symptoms was observed in all of these surgically treated cases. Correlation was found between the response to Acetazolamide administration and the appearance of B wave in the continuous spinal pressure monitoring. This study suggests that Acetazolamide test may be useful diagnostic test to select the patients for shunt operation.
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PMID:[Changes in CSF pressure induced by acetazolamide administration test--as an indicator of shunt operation for so-called normal pressure hydrocephalus]. 205 21

We report a case of a male newborn delivered by vacuum at 40 weeks of gestation, who presented perinatal asphyxia, neonatal seizures and ventricular posthemorrhagic dilatation. The newborn was treated with Acetazolamide for 45 days until the reduction of the ventricular dilatation. This case shows the efficacy and the absence of collateral effects of Acetazolamide. This therapy suggests that it may be used as an alternative or an adjunct to lumbar punctures. The pharmacol treatment in the posthemorrhagic ventricular dilatation has not been well studied and there are a few related cases in the literature.
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PMID:[Acetazolamide treatment of a newborn infant with posthemorrhagic cerebral ventricular dilatation]. 749 34

Summary The case is described of a 12-year-old girl presenting with raised intracranial pressure without ventricular dilatation and a type 1 Chiari malformation. This was taken to be a coincidental association of pseudotumour cerebri and the Chiari malformation. Treatment of the pseudotumour with Diamox gave rapid and sustained relief of the intracranial hypertension without change in the Chiari malformation. In addition, a series of 156 cases of pseudotumour cerebri was reviewed for evidence of the Chiari malf ormation. An overall incidence of 1.3%, rising to 2.7% in patients with MR scanning [excluding the case described] was found.
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PMID:Pseudotumour cerebri occurring in association with the Chiari malformation. 1174 33