Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0264733 (ventricular dilatation)
 2,163 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 5-year-old, 29-kg, female Labrador retriever developed tachypnea, tachycardia, and ataxia following ingestion of approximately 48 mg/kg of phenylpropanolamine. Initial diagnostic tests showed multiform ventricular tachycardia, left ventricular dilatation with a focal dyskinetic region in the dorsal interventricular septum, and elevations in creatinine kinase and cardiac troponin I. All abnormalities resolved within 6 months. The transient electrocardiographic, echocardiographic, and biochemical abnormalities were consistent with myocardial necrosis from infarction or direct catecholamine-induced myocardial toxicity.
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PMID:Cardiac toxicity from phenylpropanolamine overdose in a dog. 1626 67

Pulmonary tumor thrombotic microangiopathy is a rare form of pulmonary tumor embolism clinically indistinguishable from pulmonary thromboembolic disease. It is characterized by fibrocellular intimal proliferation of small pulmonary arteries and arterioles in patients with intraluminal tumor embolization. We report the case of a 67-year-old Caucasian woman who had been treated for breast cancer 5 years prior to presentation and had been free of recurrence on routine clinical surveillance. She was admitted for evaluation of three witnessed syncopal events accompanied by tachypnea and hypotension. Transthoracic echocardiography revealed severe right ventricular dilatation and severely reduced right ventricular function. Shortly after admission, the patient became acutely unresponsive and expired despite aggressive resuscitation measures. The proximate cause of death was a rupture of the right ventricular free wall and a large hemopericardium. Histopathology revealed extensive microscopic occlusions of small pulmonary arteries and arterioles by metastatic breast carcinoma with superimposed acute thrombi. Pulmonary tumor thrombotic microangiopathy should be included in the differential diagnosis of patients presenting with symptoms of pulmonary thromboembolism and a history of malignancy. <Learning objective: Pulmonary tumor thrombotic microangiopathy is a rare form of pulmonary tumor embolism clinically indistinguishable from pulmonary thromboembolic disease. It is characterized by fibrocellular intimal proliferation of small pulmonary arteries and arterioles in patients with intraluminal tumor embolization. The disease has a fulminant course and poor prognosis. It should be included in the differential diagnosis of patients presenting with symptoms of pulmonary thromboembolism and a history of malignancy.>.
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PMID:Pulmonary tumor thrombotic microangiopathy associated with right ventricular rupture and hemopericardium: A case report. 3053 33