Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0264733 (ventricular dilatation)
 2,163 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A complex angiographic examination was performed in 28 patients with rheumatic aortic valvular disease. The major mechanism of compensation in aortic failure was found to be an increase in left ventricular end-diastolic volume at the expense of added regurgitating blood volume. It was shown that isolated aortic failure was a good compensated defect with high functional myocardial reserves and coronary circulation along with adequate left ventricular dilatation and normal-stress nature of left ventricular hypertrophy. Left ventricular dilation at a regurgitation fraction of less than 30% and intramyocardial tension increase were demonstrated to be unfavorable predictive signs and to be indicative of profound myocardial dysfunction.
 ...
PMID:[Intracardiac mechanisms of compensation of isolated aortic insufficiency]. 215 56

Patients who have asymptomatic aortic valvular disease with normal systolic ventricular function need careful follow-up, because both aortic stenosis and aortic regurgitation are potentially life-threatening. Medical therapy may be helpful for long-term management of patients with chronic aortic regurgitation, but valve replacement should be done before heart failure or refractory left ventricular dilatation develops. Aortic valve replacement is recommended in patients with symptomatic, severe aortic stenosis because of the high risk of sudden death if left untreated. Once valve replacement is indicated for either aortic stenosis or regurgitation, a choice must be made between a mechanical and a bioprosthetic valve, although allografts and autografts may become more widely used in the future.
 ...
PMID:Aortic valvular disease in adults. A potentially lethal clinical problem. 760 42