Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0264733 (ventricular dilatation)
 2,163 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pulmonary hypertension associated to HIV infection has been reported in the literature with increased frequency. Apparently, this condition has a faster clinical evolution and a higher mortality than primary pulmonary hypertension. The pathogenic mechanisms of HIV associated pulmonary hypertension and the influence of its treatment on patient's evolution are not well known. We report a 32 years old homosexual male that developed a severe dyspnea in a period of 2 months. Echocardiogram demonstrated right ventricular dilatation and a systolic pulmonary artery pressure of 86 mm Hg. No other causes for pulmonary hypertension were found. Antiviral therapy and vasodilator treatment with a calcium channel blocker were started and the patient had an important subjective clinical improvement.
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PMID:[Pulmonary hypertension and HIV infection: report of a case]. 1083 59

Pulmonary hypertension is characterised by the chronic elevation of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR) leading to right ventricular enlargement and hypertrophy. Pulmonary hypertension may result from respiratory and cardiac diseases, the most severe forms occurring in thromboembolic and primary pulmonary hypertension. Pulmonary hypertension is most often defined as a mean PAP >25 mmHg at rest or >30 mmHg during exercise, the pressure being measured invasively with a pulmonary artery catheter. Doppler echocardiography allows serial, noninvasive follow-up of PAPs and right heart function. When the adaptive mechanisms of right ventricular dilatation and hypertrophy cannot compensate for the haemodynamic burden, right heart failure occurs and is associated with poor prognosis. The haemodynamic profile is the major determinant of prognosis. In both primary and secondary pulmonary hypertension, special attention must be paid to the assessment of pulmonary vascular resistance index (PVRI), right heart function and pulmonary vasodilatory reserve. Recent studies have stressed the prognostic values of exercise capacity (6-min walk test), right atrial pressure, stroke index and vasodilator challenge responses, as well as an interest in new imaging techniques and natriuretic peptide determinations. Overall, careful haemodynamic evaluation may optimise new diagnostic and therapeutic strategies in pulmonary hypertension.
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PMID:Haemodynamic evaluation of pulmonary hypertension. 1244 89

A rare case of primary pulmonary hypertension was observed in a 73-year-old man. Angina pectoris was diagnosed at the age of 67 and he received several percutaneous coronary interventions because of refractory restenosis. He also had coronary artery bypass surgery at the age of 69. After 4 years, he again suffered from dyspnea and chest pain upon physical exertion. On admission to our hospital, a chest radiograph showed dilatation of bilateral pulmonary arteries. Moreover, echocardiography showed right ventricular dilatation and tricuspid regurgitation. Continuous wave Doppler imaging revealed a pressure gradient of 82.1 mmHg. Pulmonary capillary wedge pressure was normal, but pulmonary artery pressure was elevated upon cardiac catheterization. Because there was no apparent etiology of pulmonary hypertension, primary pulmonary hypertension was diagnosed and appropriate conventional therapy was started.
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PMID:[A 73-year-old man with primary pulmonary hypertension]. 1573 71

An 18-year-old woman presented with primary pulmonary hypertension (PPH) and was hospitalized because of hemoptysis and was referred to our department for a differential diagnosis pulmonary thromboembolism. Doppler ultrasonography of the lower extremities was normal. Echocardiography and cardiac catheterization showed right ventricular dilatation and increased pulmonary artery pressure without anatomic (intracardiac) shunt. The mean pulmonary arterial pressure was 110 mm Hg. Tc-99m MAA lung perfusion scans showed nonsegmental patchy defects. Extrapulmonary renal uptake and increased systemic deposition of radiotracer were seen in the MAA scintigraphy. It could be related to a functional intrapulmonary shunt resulting in increasing pressure in the pulmonary artery in PPH.
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PMID:Renal uptake on lung perfusion scintigraphy in a patient with primary pulmonary hypertension. 1582 3

A 45-year-old man, who had been diagnosed with primary pulmonary hypertension (PPH) 8 years before, was referred to our hospital because of short breath and lower-limb edema. Findings of chest X-ray, electrocardiogram, and cardiac ultrasound showed right atrial and ventricular dilatation/hypertrophy that were compatible with advanced PPH. Chest enhanced computed tomography (CT), however, unexpectedly showed that contrast in the main pulmonary artery was diluted by blood flow from the descending aorta. On electrocardiography-synchronized CT, the arterial duct connecting the main pulmonary artery and descending aorta was clearly delineated. As a result, the long-standing diagnosis of PPH was corrected to secondary pulmonary arterial hypertension caused by patent ductus arteriosus, thanks to the "reverse" enhancement on CT.
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PMID:Enhanced computed tomography unveiling the underlying cause of pulmonary hypertension. 1995 26