Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Differential diagnosis of sonographically detected fetal neck tumours is difficult. The sonographic criteria for encephalomyelocele, lymphangioma/hygroma, teratoma, sarcoma, haemangioma, neuroblastoma and goitre are given on the basis of the authors' own observations and information from the literature. Elevation of alpha-fetoprotein in the amniotic fluid is a frequent but non-specific finding. Chromosome analysis after amniocentesis can be a useful supplementary procedure for assessing the prognosis and deciding upon the delivery procedure. Sonographic detection of a tumour in the fetal neck region enables preparations to be made for dystocia and postnatal dyspnoea of the newborn. The obstetrician must cooperate closely with paediatricians, neurologists, surgeons and ENT specialists.
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PMID:Differential diagnosis of sonographically detected tumours in the fetal cervical region. 389 70

Seventeen cases of ataxia telangiectasia (AT) were diagnosed over a period of 10 years. The children affected by AT were aged about 7 years and they were preferentially males (67%). The principal clinical aspects were: cerebellous ataxia (98%), recurrent ENT infections (86%) and ocular telangiectasia (96%). We also showed an immune function defect mainly concerning IgA, which was associated with cellular immunity abnormalities (lymphopenia, negative hypersensitivity reactions). The alpha-fetoprotein (AFP) values were high and increased in proportion to the severity of the neurologic manifestations. Thus, this parameter could be used as a diagnostic index of the illness and could be a precious indicator for the management and the evolution of these patients.
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PMID:[Ataxia telangiectasia. Clinical and biological study in 17 cases]. 752 81

Ninety-two nasopharyngeal carcinoma (NPC) patients were selected for a study to measure tissue polypeptide antigen (TPA), CA 125, CA 19-9, carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP). In all, 32 patients with chronic ENT disease and 40 healthy persons were asked to participate as diseased and normal control groups. The results showed (1) TPA was the most effective of all markers; (2) CA 125 was less useful, but had a definite correlation with TPA; (3) CA 19-9, CEA, and AFP were nearly useless; (4) the TPA level increased with advancing tumour, nodal stage, and stage groups; (5) when metastases occurred, the TPA level was extremely high; (6) the TPA level decreased significantly after irradiation at stages II, III, and IV, but increased at stage V; and (7) there was no difference in TPA level between the nonkeratinizing and undifferentiated carcinomas. This study demonstrated that the TPA marker was useful in determining the degree of NPC severity and especially for indicating the presence of metastatic disease.
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PMID:Significance of tumour markers in nasopharyngeal carcinoma. 881 7