Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although photodynamic therapy (PDT) for the treatment of head and neck cancer has proved useful in other departments (J. Feyh, A. Goetz and W. Muller, Photodynamic therapy in head and neck surgery, J. Photochem. Photobiol. B: Biol., 7 (1990) 353-358; V.G. Schweitzer, Photodynamic therapy for treatment of head and neck cancer, Arch. Otolaryngol. Head Neck Surg., 102 (1990) 225-232; B.L. Wenig, D.M. Kurtzmann and L.I. Grossweiner, Photodynamic therapy in the treatment of squamous cell carcinomas of the head and neck, Arch. Otolaryngol. Head Neck Surg., 116 (1990) 1267-1270), it is not a standard therapy at the ENT Department of the University Clinic Innsbruck. PDT has only been applied in a few selected cases. Photosan 3 (dihaematoporphyrin either, DHE) was used as photosensitizer at a dose of 2.5 mg (kg body weight)-1 administered intravenously 24-48 h prior to photoirradiation. In one case, Photosan 3 was applied topically in a solution with 40% dimethylsulphoxide (DMSO). The light source was an argon dye laser with a wavelength of 630 nm and a power of 100 mW cm-2, coupled with a cylindrical or spherical applicator and a lens fibre tip. Patients suffering from cancer of the palatine arch, tonsil, nasal septum and glottis are reported. These selected cases had previous treatment (e.g. chemotherapy, percutaneous irradiation and surgery), and PDT was either performed as a palliative treatment for recurrence or in elderly patients to avoid inappropriate extensive and mutilating surgery.
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PMID:Photodynamic therapy in selected cases at the ENT Clinic, Innsbruck: case reports. 900 58

Spores of Curvularia lunata were immobilized by entrapment with photo-cross-linkable resin prepolymers and incubated to form mycelium in potato dextrose broth containing cortexolone (Reichstein compound S) as an inducer of steroid 11beta-hydroxylase. In a buffer system containing 2.5% dimethyl sulfoxide, this immobilized mycelium hydroxylated cortexolone to hydrocortisone. The activity of this mycelium was comparable to the activity of free mycelium. Dimethyl sulfoxide did not inhibit hydroxylase activity at the concentration used and was effective in dissolving the product. Of the various photo-cross-linkable resin prepolymers examined, use of ENT-4000, whose main chain was polyethylene glycol 4000 (chain length, approximately 40 nm), resulted in maximum hydroxylation activity of the entrapped mycelium. The chain length of prepolymers affected markedly mycelial growth in the gels and, subsequently, the activity of the entrapped mycelium. The immobilized hydroxylation system was more stable than the system in free mycelium and could be reactivated by incubation of the entrapped mycelium in potato dextrose broth containing cortexolone. The system was tested 50 times during 100 days of operation and was found to carry out the desired transformation with overall yields of 60%.
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PMID:11beta-Hydroxylation of Cortexolone (Reichstein Compound S) to Hydrocortisone by Curvularia lunata Entrapped in Photo-Cross-Linked Resin Gels. 1634 94