Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The alleviation of vestibular distress using drug therapy is a question of whether treatment with drugs is advisable at all or whether more emphasis should be directed towards active habituation therapy. Histamine and especially its derivative, betahistine, inhibit the massive impulses to the polysynaptic neurons of the lateral vestibular nucleus without having any sedative effect, as measured by saccadic eye movements. In the ENT Clinic of Turku University Hospital, betahistine has been used to treat 613 Meniere's patients at a dose of 8 mg three times daily. In about 80% of these patients, the results of therapy were positive. Betahistine is the current most effective drug in maintenance therapy of Meniere's disease, although it does not resolve all of the problem of this disorder. Betahistine can also be used in other forms of vestibular vertigo as maintenance therapy, because it only has minimal side-effects and it has not been shown to slow down habituation.
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PMID:Treatment of acute vestibular vertigo. 206 40

Histamine(1), receptor antagonists are being prescribed frequently in ENT practice. However, previously we found a fall of blood glucose with terfenadine and astemizole. Present study (double blind, randomized, single dummy and placebo controlled) evaluated the chronic effect (7 days of use) of clemastine, Loratidine and Certrizine on blood glucose level in patient of allergic rhinitis. Cetrizine produced a significant increase in post-prandial blood glucose (P<0.02) and a little rise in fasting blood glucose. Clamastine caused a little fall of fasting and a little rite of post-prandial blood glucose levels. The exact mechanisms involved in the effect of these drugs on blood glucose remain to be elucidated.
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PMID:Effect of a few histamine(1)-antagonists on blood glucose in patients of allergic rhinitis. 2311 74