Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0262471 (
ENT
)
5,307
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Expression of
intercellular adhesion molecule-1
(
ICAM-1
) on targets has been reported to be a relevant factor for leukocyte migration, adhesion and function. Because stimulated chondrocytes have been shown to express molecules of immunological import (like HLA class II antigens) and because rejected or resorbed cartilage grafts used in the field of
ENT
are often characterized by adjacent infiltrating leukocytes, the presence of
ICAM-1
on human nasal, auricular and costal cartilage was investigated. For this study, cartilage tissue sections and chondrocytes in suspension as well as cultured chondrocytes were prepared. Specific monoclonal antibodies (mAb) were used for immunocyto- and immunohistochemical Alkaline-Phosphatase-anti-Alkaline-Phosphatase staining (APAAP staining) as well as for flow cytometry analysis.
ICAM-1
on healthy cartilage tissue sections was not found. On the other hand, both chondrocytes freed from matrix and cultured chondrocytes showed strongly positive staining patterns for
ICAM-1
. This result was obtained for chondrocytes from nasal, auricular as well as costal cartilage. This observed expression of
ICAM-1
on chondrocytes with defective extracellular matrix demonstrates that cartilage cells are able to synthesize
ICAM-1
without any paracrine stimulus from non-chondrocyte cells. It suggests that
ICAM-1
plays a role in processes where tissue damage leads to the exposure of chondrocyte surfaces. Therefore,
ICAM-1
expression on chondrocytes may also be a factor in destructive cartilage graft resorption.
...
PMID:Expression of ICAM-1 on isolated human nasal, auricular and costal chondrocytes. 751 Apr 48
