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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chemotherapy of malignant ENT tumours with Bleomycin (BLM) alone is not very successful. In the last time however several authors pointed out much better therapeutic results when BLM therapy has been combined with radiation treatment It is farly unknown why this combination should cause a greater therapeutic effect. Therefore we investigated the following questions: 1. In what manner does BLM influence the kinetics of cell proliferation of malignant tissues? 2. Does BLM synchronize the tumour cells or is the greater therapeutic success of a combination of BLM and X rays only depending an an additional effect? 3. Can we find a connection between the effect of BLM and the histology of the tumour? With cell kinetic methods (authoradiography, cytophotometry, mitotic index) and histological technics we examined these problems in 5 human ENT tumours and got the following results: 1. BLM initially causes a partial synchronization of the tumour cells (blockade in the S-phase). During a continuous therapy with BLM however the tumour cells will be collected in the late S- and mainly in the G2-phase. But this peak of cells in G2 is not the expression of synchronization because a lot of these cells are blocked irreversible and will leave the cell cycle (hyperceratotic cells). Ffrom those cells which thereupon have entered the mitotic phase a further part of them will by endomitosis or endoreduplication. Only a small group of the cells originally collected in the G2-phase will devide and enter the G1-phase again. Furthermore we observed a distinct recruitment of G0-cells back into the cell cycle (for details see fig. 9). 2. The greater effect of radiation therapy following the application of BLM is not the result of synchronization but of an additional destruction of premitotic G2-cells which properly would have undergone mitosis. BLM and X rays therefore act additionally. 3. The greater therapeutic success of the combination of BLM and radiation treatment comes true only in keratinizing squamous cell carcinoma. The reason is that BLM destroys the tumour cells by hyperkeratosis and polyploidy. Thus BLM must be ineffective in carcinoma without the ability of keratinizing.
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PMID:[The mode of action of bleomycin-cell kinetic investigations (author's transl)]. 7 61

For over ten years the therapy schedule of combined treatment (partial synchronisation) has been clinically tested and applied. Positive results are reported. The reasons for these positive results seem to be more the additive effects than the synchronisation. Despite some doubts concerning the effectivity of synchronisation, these so called partial synchronisation therapy has been applied since 1972 because of the encouraging own results and the positive results reported by other authors. 5 FU, Vincristine, Bleomycin and Adriamycin have been used as cytostatic drugs; the highly differentiated keratinizing squamous cell carcinomas should be treated with Bleomycin. Our report covers the results of over 100 patients with malignant ENT-tumors treated by the schedules. Most patients came with advanced inoperable tumors or recurrences after surgery and/or irradiation; the combined therapy with 5 FU Bleomycin and Adriamycin increased complications and side effects than radiotherapy alone. A recent trend is to use Bleomycin or Adriamycin as cytostatic drugs. The breakdown of survival rates according to the tumor localisation shows the best 5 year survival times of patients with laryngeal/hypopharyngeal carcinomas (advanced tumors respectively recurrences). This combined therapy leading to a surprising remission in a short time and to a prolongation of life with supportable feelings, seems to be an usefull supplement of therapeutical methods in advanced ENT-tumors.
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PMID:[Combined cytostatic-radiologic therapy of advanced malignant tumors in otorhinolaryngology. Experiences and results with over 100 patients]. 721 93

Keloids are fibroproliferative extreme variants of an impaired wound healing, developing a tumour-like growth. In the ENT area keloids arise mainly at auricle. Often caused by piercings or trauma. They grow bulging excessively over the original scar edges and adopt sometimes bizarre morphologies. The patients complain often of dysesthesias such as burning pain, severe itching and are suffering often from stigmatization. The huge number of therapy methods, for the treatment of keloids described in the literature (silicon therapy, compression, intralesional corticoids, intra- or extralesional surgical excision, kryosurgery, radiatio, Interferon- or Bleomycin-therapy) emphasize the enormous challenge for the treating doctor, particularly in facial plastic surgery.
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PMID:[Functional and aesthetic therapy concepts of keloids in the head- and neck area]. 2451 18