Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

For over ten years the therapy schedule of combined treatment (partial synchronisation) has been clinically tested and applied. Positive results are reported. The reasons for these positive results seem to be more the additive effects than the synchronisation. Despite some doubts concerning the effectivity of synchronisation, these so called partial synchronisation therapy has been applied since 1972 because of the encouraging own results and the positive results reported by other authors. 5 FU, Vincristine, Bleomycin and Adriamycin have been used as cytostatic drugs; the highly differentiated keratinizing squamous cell carcinomas should be treated with Bleomycin. Our report covers the results of over 100 patients with malignant ENT-tumors treated by the schedules. Most patients came with advanced inoperable tumors or recurrences after surgery and/or irradiation; the combined therapy with 5 FU Bleomycin and Adriamycin increased complications and side effects than radiotherapy alone. A recent trend is to use Bleomycin or Adriamycin as cytostatic drugs. The breakdown of survival rates according to the tumor localisation shows the best 5 year survival times of patients with laryngeal/hypopharyngeal carcinomas (advanced tumors respectively recurrences). This combined therapy leading to a surprising remission in a short time and to a prolongation of life with supportable feelings, seems to be an usefull supplement of therapeutical methods in advanced ENT-tumors.
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PMID:[Combined cytostatic-radiologic therapy of advanced malignant tumors in otorhinolaryngology. Experiences and results with over 100 patients]. 721 93

Since February 1979, 22 juvenile angiofibromas have been treated among 312 tumors of the skull base managed in the ENT Department, Fulda. According to a general staff consensus the treatment of choice was complete surgical removal. This was achieved in 20 cases with one operation and in one case with two operations. In addition to removal of tumor, functional and aesthetic aspects had to be considered as aims of operative treatment, including among others preservation of the facial skeleton, infraorbital nerve, nasolacrimal drainage system and vision. In rare cases complete excision of the tumor is not possible. The value of cytostatic therapy is demonstrated in one patient with uncommonly advanced disease. Considering the extensive regression of tumor achieved in this case after chemotherapy with Adriamycin and decarbazine, one has to raise the question if the chemotherapeutic approach was more than just palliative. From our experience chemotherapy should be considered a possible alternative to radiation in the management of unresectable juvenile angiofibromas.
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PMID:[Chemotherapy of juvenile angiofibroma--an alternative?]. 864 2