Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to evaluate effectiveness and safety of tiaprofenic acid (TA), a multicenter study involving outpatients followed by ENT specialists was carried out. Since October 1988, the trials have prospectively enrolled 4231 patients. The demography of the study's population was: 2165 male and 2066 female, mean age 39.6 +/- 15.8 years. The patients were divided into the following groups by pathology: 1281 (30.4%) otitis, 654 (15.5%) rhinosinusitis, 2178 (51.6%) pharyngo-laryngo-tonsillitis, and 112 (2.6%) flue syndrome, 300 mg b.i.d. of TA was orally administered for seven consecutive days. At T0 and T7 parameters ranged from 75-90% for symptoms related to inflammation of the oral tract, 80% for nasal edema and 100% for otalgia. The physician's judgement about the drug's effectiveness was 90.6% excellent or good. Side effects were reported in 409 cases (9.6%) mainly related to the gastrointestinal tract. There were 72 drop-out (1.7%): 38 (0.9%) for drug intolerance. In conclusion, TA showed excellent safety and effectiveness in improving the recovery of ENT's outpatients.
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PMID:[Efficacy and tolerance of tiaprofenic acid in acute inflammatory ORL diseases: a multicenter study of 4231 patients]. 224 31

A 26-year old male patient was referred to us for impaired mouth opening. Actually, Mr. B. has been followed up for SADAM for 2 years at different hospital services. In view of the ineffectiveness of the treatments administered (occlusal releasing gutter, antiinflammatory agents) and due to occurrence of severe episodes of earache refractory to conventional analgesics, we request that a CT-scan be obtained to evidence the process invading the pterygopalatine fossa. ENT examination and scanner-guided needle biopsy are performed to enable anatomopathological analysis and diagnosis.
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PMID:[Scanner-guided puncture biopsy of a lesion occupying the pterygo-maxillary fossa]. 229 Oct 88

Two patients with sudden progressive profound hearing loss resulting from Ramsay Hunt syndrome are reported. Case 1: A 63-year-old woman was admitted to Jichi Medical School Hospital with sudden, progressing deafness of the left ear, vertigo, sore throat, and hoarseness. An otoscopic examination revealed the external ear and the tympanic membrane to be normal. Pure-tone audiometry revealed profound deafness in the left ear. A horizontal nystagmus in the non-affected direction was observed by gaze nystagmus test. An endoscopic examination revealed herpetic vesicles and shallow ulcers on the left side of the pharynx and the larynx. There was complete paralysis of the left recurrent nerve. Hearing acuity of the left ear did not recover at all with steroid hormone therapy. Case 2: A 75-year-old man was referred to the ENT Clinic by a dermatologist for hearing evaluation in Ramsay Hunt syndrome. The man had noticed severe otalgia and sudden progressive deafness of the right ear approximately 2 weeks prior to admission. Physical examination revealed herpetic vesicles and ulcers in the right external ear and lateral neck. Complete paralysis of the right facial nerve was noted. Profound hearing loss in the affected ear was observed by pure-tone audiometry. A gaze nystagmus test revealed a horizontal nystagmus in the non-affected direction. No recovery of the cochlear function was noted following administration of antiviral drug. The pertinent literature is briefly reviewed.
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PMID:Acute profound deafness in Ramsay Hunt syndrome. Two case reports. 285 31

A number of typical ENT complaints which do not involve organic signs or symptoms are presented, such as sinusitis-like headache, otitis-like earache and tonsillo-pharyngitis-like dysphagia. Since patients with such complaints usually visit an ENT specialist first, an introduction of additional diagnostic and therapeutic measures is imperative. Without having been trained in chirotherapy, it is possible to identify painful locations, myogeloses and functional disorders in the craniocervical area. In many cases treatment of these disorders leads to disappearance of associated irritational complaints. In addition to local treatment of the neck, the ENT specialist may employ a procedure as described. Superficial infiltration of the mucous membrane is performed with a local suprarenin-free anaesthetic in an area around the upper wisdom tooth and on the palatoglossal arch. This procedure often leads to spontaneous and lasting relief of symptoms. It is assumed that this has the effect of inhibiting the pathologically irritated afferents and thus of interrupting an altered reflex arc. Relief from the complaints is improved by physiotherapy and by avoiding the detrimental influence of bad posture, nervous stress, air draughts, cold chills etc. Extensive massage therapy can result in worsening of complaints.
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PMID:[Neck-induced myoneural irritation pain--a recommendation for therapy by the ENT physician]. 328 78

Headaches are a frequent symptom in ENT-patients. The complex sensory innervation of the ear, nose and paranasal sinuses is demonstrated. Heterotopic or referred pain must be differentiated from homotopic pain that is experienced at the point of injury. The nervous pathways of heterotopic otalgia are shown. The quality of pain of the most common rhinological and otological diseases is reported.
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PMID:[Headaches caused by ENT diseases]. 638 2

A small series of pain syndrome patients shows that disturbances of the head and neck motor system can lead to various pain syndromes as the vicious circle between pain and muscle tension is initiated by a triggering factor. These pain syndromes include varying combinations of the following symptoms: headache, referred otalgia, arthralgia of the temporomandibular joint, styloid syndrome, tendopathia of the hyoid bone, carotidynia, cervical dysphagia and probably most patients with superior laryngeal nerve neuralgia or glossopharyngeal neuralgia. A detailed differentiation of those syndromes is of little value for diagnostic and therapeutical purposes, because the mixed distribution of the pain irradiation does not indicate the localisation of the primary pathology. The pain syndromes of the head and neck motor system can be caused by temporomandibular joint pathology as well as by anatomical or functional alterations of the cervical spine. Acute exacerbations are triggered off by various influences such as inflammation, trauma, scarring after surgery or radiotherapy. Thus diagnostic and therapeutic measures must take into consideration both the motor system itself and any possible triggering factors. The problem frequently needs interdisciplinary co-operation. An attempt to handle the problem within the boundaries of a single discipline such as ENT, may lead to unnecessary and misleading steps. Guidelines for the management of such pain syndromes are outlined.
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PMID:[Pain syndromes of the head, neck and locomotor system--determining current status]. 674 25

Among controversies in pediatric otorhinolaryngology, the role of gastroesophageal reflux (GER) in inflammatory disorders of the upper airway remains of major concern. A laryngeal involvement by GER was demonstrated in adults and a correlation with GER has been found in pediatric populations with recurrent croup. However, although considered statistically significant, these results concern a few patients only and are inconclusive for a causal relationship. In addition, pH monitoring, often considered as the gold standard for the diagnosis of GER disease, has failed in giving normal values in ENT disorders. Eventually, upper pharyngeal and nasal involvements by GER and GER-related otitis media or otalgia have been suggested by some authors. In the 6th International Congress on Pediatric Otolaryngology, the Symposium on GER was designed to help physicians in improving their knowledge of the data from the literature and their understanding of the involved mechanisms. Bearing in mind the potential severity of GER disease, the audience also heard and debated the most up-to-date methods of assessing GER and treating it in patients with possibly related otorhinolaryngological symptoms. Here is the summary of this symposium.
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PMID:Gastroesophageal reflux and ENT disorders in childhood. 1644 7

The importance of the cervical spine in routine ENT practice is discussed, using the example of otalgia due to disorders of the cervical vertebra: Evaluation and follow-ups of 13,000 patients showed that 6% had diseases caused by the cervical spine. Frequency, pathophysiology and treatment results of cervicogenic otalgia are presented. The principles of adequate functional diagnostics and therapy of cervical spine disorders are explained.
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PMID:[Earache and functional disorders of the cervical spine]. 802 Nov 52

In most patients the first symptoms of Wegener's granulomatosis (WG) originates in the ENT-area. As a consequence, their prompt recognition allows diagnosis of the disease in an early stage. The beginning of WG with initial symptoms of otalgia followed by a rapidly progressive course is reported in a case. Prognosis in WG currently depends on making an early diagnosis and is improved by well-timed and sufficient therapy.
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PMID:[Initial otologic manifestation of Wegener's granulomatosis]. 816 96

Hyperbaric oxygen therapy is associated with a risk of barotrauma to the middle ear. This prospective study of 82 patients undergoing long-term therapy for chronic conditions was designed to measure the incidence and severity of middle ear barotrauma. Twenty-four patients (29.3%) required the insertion of ventilation tubes for otalgia, significantly more of whom were suffering from radionecrosis of the head and neck region (P < 0.01). Thirty-two of the remaining 58 patients (55%) underwent specialist ENT assessment by otoscopy and tympanometry. Five ears (8%) showed the otoscopic changes of barotrauma (TEED grade 3 or 4), and one ear (2%) showed tympanometric evidence of a middle ear effusion (Type B tympanogram). We conclude that despite careful tuition in pressure equalization and the appropriate use of ventilation tubes, up to 8% of ears sustain significant barotrauma. Tympanometry is unreliable in detecting these changes, otoscopy provides the most reliable screening technique.
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PMID:Middle ear barotrauma in patients undergoing hyperbaric oxygen therapy. 893 42


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