Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We performed a randomized double-blind controlled study in community medical practice comparing lysine acetylsalicylate (LAS) and paracetamol (PAR). Both drugs were given at the same dose (1 g, thrice daily) during two days; from the third to the seventh day, the patients could freely take the same drug if necessary. The analgesic effect of drugs was measured by two means: an analog scale of pain during day 1 & 2 and the count of drugs units taken during days 3 to 7. The side effects were reported. We included 473 patients (167 men, 306 women) by means of a group of 54 general practitioners. 470 patients were stratified according to the site of pain: head (n = 113), joints (n = 80), back (n = 193), thorax (n = 11), teeth (n = 48), ENT (n = 25). The pain was either acute (73%) or chronic (27%) and scored an average +/- SD of 76 +/- 12 mm on an analog visual scale from 0 to 100 mm. Response was defined as a decrease of at least 50% of the pain score. Before intake of active drugs, all patients were given placebo. Only 14% responded. Under LAS or PAR, although the difference is not statistically significant, the number of responders was slightly higher with LAS than with PAR. Moreover, the study yields some interesting differences. During day 1 and day 2, the patients of the LAS group had less pain than those of the PAR group. This difference became statistically significant at D2 H12 (p < 0.05). LAS was significantly more effective than PAR in patients with back pain (p < 0.01), and there was a trend in favor of LAS in dental and ENT pain, and for intense pain. PAR never yielded better response levels than LAS. Among the placebo-unresponsive patients, the amount of drug taken from day 3 to day 7 was significantly lower in the LAS group than in the PAR group (p < 0.05). The side effects were comparable in both groups. According to the investigators' point of view both drugs were similarly well accepted by the patients (89.3% in LAS group, 94% in PAR group). The fact that LAS seems more effective than PAR in some kinds of pain is to bring near to the anti-inflammatory action of LAS and to its better bioavailability.
 ...
PMID:[Comparative trial of lysine acetylsalicylate and paracetamol on pain in daily medical practice]. 895 56

Back and neck pain is an established occupational disease for many professions. No previous studies have shown the association of back and neck pain with ENT surgery. Our objective was to determine the prevalence of neck and back pain in ENT consultants in the United Kingdom and which sub-specialties were most at risk. A national survey from 325 ENT consultants in the UK revealed that 72 per cent had either back pain or neck pain or even both. Of those with pain 53 per cent attributed their symptoms directly to ENT surgery. Highest figures were received from otologists, related to microscope work and prolonged sitting. The importance of these findings has demonstrated the lack of awareness and adequate training to prevent long-term disability in ENT surgeons.
 ...
PMID:Prevalence of back and neck pain amongst ENT consultants: national survey. 1516 22

We examined the use of telemedicine for improving access to care in a work-site clinic. A prospective study of 100 patients was conducted over a four-month period in a work site that housed 700 employees. Sinusitis (10 visits), upper respiratory tract infections (9 visits), otitis media (9 visits), hypertension (9 visits) and back pain (8 visits) were the most common reasons for the visits. In 99 visits, clinicians were of the opinion that the telemedicine visit felt similar to a face-to-face visit. For most of the visits (67), patients strongly agreed or agreed that telemedicine had a positive effect on their relationship with the health-care provider. The otoscope, microscope and stethoscope telemedicine peripherals were important in aiding diagnosis (and ruling out other causes) in about 55% of the visits (upper respiratory tract infection, sinusitis, otitis media, cough, sore throat, nevi, rhinitis and ear wax related concerns). The ability for the patient to watch their ENT examination and see any associated abnormalities was appreciated by many patients. Physicians, nurses and patients were capable of using the technology with little training.
 ...
PMID:Telemedicine in the work site: a study of feasibility, and patient and provider satisfaction. 1877 79

A 37-year-old patient was transferred to Haematology from the ENT Emergency Department where he had been admitted due to tonsillitis. He displayed anaemia and leukopenia and had agranulocytosis in the study. A day later the patient had blast crisis, and was diagnosed with myeloid acute leukaemia. Due to blast crisis the patient experienced sudden back pain, with oliguria and renal function deterioration followed by anaemia, in the context of haemolysis consistent with thrombotic microangiopathy, and as such, we were consulted. We began treatment with plasmapheresis and on the following day we performed haemodialysis (we carried out a total of 12 sessions of plasmapheresis until haemolysis disappeared). Five days later there was respiratory failure, and the patient was consequently transferred to the Intensive Care Unit, where he continued treatment with plasmapheresis and haemodialysis. The patient remained anuric thereafter, requiring haemodialysis, with no sign of renal recovery. Once platelet levels normalised with haematology chemotherapy, a percutaneous renal biopsy was performed, which confirmed the diagnosis of cortical necrosis. Finally, the patient underwent renal replacement therapy by regular haemodialysis.
...
PMID:Renal cortical necrosis secondary to thrombotic microangiopathy in the context of acute promyelocytic leukaemia blast crisis. 2424 70

A sixty-one year old man was referred with a history of progressive dysphagia, vomiting and weight loss with some back pain. Upper gastrointestinal endoscopy and biopsies revealed a gastro-oesophageal junction adenocarcinoma. Despite the absence of metastatic disease on computed tomography, positron emission tomography demonstrated multiple vertebral and sternal deposits. He was reviewed in an ENT clinic with a sudden onset of hearing loss accompanied by dizziness, but no focal neurology. Magnetic resonance imaging identified bilateral 2cm lesions at the internal auditory meatus, consistent with a diagnosis of bilateral acoustic neuromas. The patient subsequently died of carcinomatosis and, because of the potential familial significance of bilateral acoustic neuromas, a limited post-mortem examination was carried out. Unexpectedly, this revealed bilateral adenocarcinoma metastases infiltrating the internal auditory meatus affecting the acoustic nerves. The authors believe this a very rare presentation of metastatic gastric disease.
...
PMID:Hearing loss as an unusual consequence of metastatic gastric adenocarcinoma. 2494 49