Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The fact that ENT doctors infrequently diagnose hemophilia is explained by their inadequate knowledge of the disease. We examined 35 patients suffering from hemophilia A and 3 patients suffering from hemophilia B. The most frequent ENT pathology in them was relapsing nasal hemorrhages of varying intensity and duration (20 patients). Chronic tonsillitis was identified in 17 hemophiliacs. In 2 patients, angina was aggravated by hemorrhages from the tonsils and life-threatening hemorrhages to the soft tissues of the pharynx, neck and mediastinum which led to airways stenosis. In 3 patients, adenoids of the I degree and in 5 patients, adenoids of the II degree were detected. Among other ENT pathologies mention should be made of deformed nasal septum (13 cases), chronic otitis media (4 cases) and chronic suppurative mesotympanitis (1 case). In summary, the most common ENT disease in hemophiliacs is pathology of the lymphadenoid pharyngeal ring detected in more than half of the patients examined. Taking into consideration the specific and life-threatening pattern of potential complications of this pathology, it is important to choose efficient therapeutic methods.
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PMID:[Specific features of otorhinolaryngologic diseases in patients with hemophilia]. 231 11

Acute epiglottitis in adults is a potentially fatal but self-limiting disease of increasing incidence world-wide. Forty-two patients, seen consecutively over a four year period at the ENT Department, Singapore General Hospital were reviewed retrospectively. A strong male predominance with a peak age incidence in the sixth decade was noted. A severe sore throat and dysphagia with disproportionate signs of oropharyngeal inflammation was the main presenting picture. Only three patients had stridor on presentation. Vigilant monitoring of the airway with empirical high-dose intravenous ampicillin, cloxacillin and steroids resulted in a dramatic clinical improvement in most patients and none developed stridor after admission. The yield from throat swabs and blood cultures were low. Two patients developed complications, a Ludwigs angina and an epiglottic abscess. Recurrent epiglottitis was a problem in one patient. There was low morbidity and no mortality on the management regime outlined.
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PMID:Acute epiglottitis in adults (the Singapore experience). 320 35

The problem of diagnosis of diphtherial infection has come to acquire especially significance at the present stage because here in Ukraine we have no legitimate standard procedure for identification of a case of diphtheria and because interpretation of results of bacteriological and serological studies in patients who might have diphtheria is often faulty. The diagnosis of atypical cases of mild localized diphtheria in the vaccinated subjects relies on the presence of chronic ENT-affections and a history of predisposition to sore throat. It is necessary that parallel culturing be done of smears obtained from the nasopharynx for diphtheria and pathogen microflora in order that no possibility of angina of other microbe etiology might be entertained. Isolation of nontoxicogenic strains C diphtheria in the absence of clinical signs of diphtheria should not prompt us to diagnose a patients as having this problem. Serologic investigation of the patients serum in the passive hemagglutination test for the presence of antitoxic antibodies can be recommended for use to verify the vaccination history in those having been taken ill rather than to aid in the differential diagnosis of diphtheria and bacteria-carrier states. Results of bacteriological and serological investigations do not give much ground for rejection or confirmation of the diagnosis made.
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PMID:[Diagnostic problems in diphtheria infection]. 1047 59

Tonsillectomy is one of the most frequent ENT operations but yet a very disputed one. The majority of children and adults are treated for recurrent angina, which is validated by several clinical trials. For an adult a peritonsillar abscess is best treated by immediate tonsillectomy. Incision and drainage is a validated method as well, as long as there is no indication to a delayed tonsillectomy. The tonsillectomy alone is not a validated treatment for adult upper airway obstruction. On the other hand it is a recommended procedure for children upper airway obstruction. Partial tonsillectomy (tonsillotomy) is also a validated procedure for this indication. Finally the peritonsillar abscess in a child should first be treated by one or two days of intravenous antibiotics.
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PMID:[Indications for tonsillectomy in 2005]. 1630 Feb 79