Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Chordoma is a fully malignant tumor deriving from remnants of the chorda dorsalis. In ENT it mainly appears as nasopharyngeal or parapharyngeal mass, growing slowly and only very late giving rise to severe symptoms by invading the skull base and the vertebra, thus making an effective treatment sometimes almost impossible. Histologically there are two cell-lines in the tumor, which are demonstrated and explained. These different cell-types are responsible for the sometimes varying aggressiveness of the tumor and its changing response to irradiation therapy. The symptomatology and histopathology of the lesion is discussed and an attempt is made to explain the tumor's biological behaviour according to its histological composition of two different cell-lines.
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PMID:[Clinical course and histopathology of chordomas in the ENT area]. 664 40

High number of performed adenotomies inclines ENT surgeons to introduce more and more satisfying concerning safety, accuracy and results predictability surgical techniques. The aim of our study was to assess the value and safety of an endoscopic surgical technique. The study was performed on 768 patients aged 7 months - 14 years. Group A (I) consisted of 453 patients on whom adenotomy was performed with use of Beckmann adenotome. Group B (II) consisted of 315 patients operated under endoscope control with the use of Jurasz forceps. An endoscopic technique gives remarkable decrease of intraoperative blood loss and eliminates post op bleedings, what increases patients safety. Low aggressiveness of an endoscopic technique compared to classic decreases incidents of undesirable post adenotomy signs and symptoms. In authors opinion, the results obtained during study, definitely prove the superiority of endoscopic technique--it is worth of introducing into daily surgical practice.
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PMID:[Endoscopic adenotomy--clinical assessment of value and safety--an own experience]. 1760 13

Schneiderian papillomas are uncommon benign tumors of the sinonasal area. They are prone to local aggressiveness and recurrence, and some undergo malignant progression. We analyzed specimens obtained from 67 Chinese patients who had presented to the ENT department of a regional hospital with biopsy-proven schneiderian papilloma. Seven of these patients had either synchronous or metachronous carcinoma, 1 of whom had pure carcinoma in situ. For each case, we documented the morphology, immunohistochemical expression of tumor suppressor genes p53 and p16, and any association with human papillomavirus (HPV) infection as detected by either polymerase chain reaction or in situ hybridization techniques. We found that severe dysplasia and p53 positivity were strongly associated with malignant progression. Association with HPV was demonstrated in 22 of the 67 patients (33%); the association was strongest among patients with exophytic papillomas and carcinomas. The effect of HPV in papilloma oncogenesis probably begins during the early phase, while other factors are responsible for progression to carcinoma. We conclude that p53-positive, dysplastic schneiderian papillomas warrant aggressive surgical treatment.
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PMID:Schneiderian papillomas and carcinomas: a retrospective study with special reference to p53 and p16 tumor suppressor gene expression and association with HPV. 2098 55

Very often, the first doctor who examines a patient with malignant lymphoma is an ENT specialist, because non-Hodgkin lymphoma is five times more frequent than Hodgkin disease in the head and neck region. Approximately 25% of extranodal lymphoma occurs in the head and neck and extranodal presentation is twice as frequent as nodal presentation. This paper present a study of the patients from ENT, Head & Neck Surgery Clinic of Coltea Clinical Hospital, Bucharest, Romania, diagnosed with malignant lymphoma. We developed a specific scheme for collecting data about patients, together with pathology details, immunology and cytogenetic markers. We tried to establish a relation between immunologic and cytogenetic markers and the clinical evolution of non-Hodgkin lymphoma. For this study, we analyzed data regarding CD10, CD5, CD20, Bcl-2, Bcl-6, Ki67 expression obtained from 58 patients with follicular lymphoma. An attempt was made to correlate the presence of certain immunohistochemical and cytogenetic markers with the evolution and aggressiveness of the disease, and we can say that Bcl-2 is positive in all tumor subtypes, being associated relatively frequently with CD5 expression, and is a marker of poor prognosis, while Bcl-6 is positive especially in the tumor forms associated with the predominance of small cells and is a marker of favorable prognosis.
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PMID:Immunologic and cytogenetic markers expressed in non-Hodgkin lymphoma of head and neck. 2239 7