Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six cases of the rarely encountered, advanced tumours of the larynx treated in ENT Clinic of Pomeranian Medical Academy in Szczecin are presented: chondroma, rhabdomyosarcoma, neurinoma, cylindroma and 2 cases of granular cell tumour. There were certain diagnostic difficulties in rhabdomyosarcoma and chondroma cases. The immunocytochemical investigations were of decisive significance in differential diagnosis of the larynx sarcoma. In the case of chondroma there were problems with biopsy taking the tense tissue of the tumour was compressing the subglottic space. The radiological examinations turned out to be very helpful in this case. All patients were treated by surgery, two of them with rhabdomyosarcoma and cylindroma were treated by irradiation too. Observation periods were from 0.5 to 10 years. The oncological and functional results in 4 cases after partial laryngectomies turned out to be satisfactory. All larynx activities were preserved. The patient with sarcoma of the larynx died 6 years after diagnosis of neoplasm. Finally author discuss diagnostic problems and methods of treatment.
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PMID:[Rare tumors of the larynx]. 945 99

The objective of the present work was to study peculiarities of diagnostics of bone and cartilaginous tumours in the sino-paranasal region with intracranial extension, to substantiate the choice of the strategy and methods for the surgical intervention for the treatment of these neoplasms. The study included 19 patients with various bone and cartilaginous neoplasms in the craniofacial region. Diagnostics was based on computed tomography allowing for 3D reconstruction of the structures of interest, magnetic resonance imaging (with amplification whenever necessary), and angiography. It is proposed to use the microsurgical and pneumatic techniques to ensure the maximally complete removal of the tumours with a minimal injury to the surrounding tissues. The extension of fascial approach is recommended for the management of intracranially spreading tumours. This technique was used for the treatment of 9 patients (7 undergoing anterior craniofacial resection, 1 lateral craniofacial resection, and 1 subcranial resection) in combination with Moure and Denker rhinotomy. The transcranial approach was employed in 8 patients one of whom underwent transoral surgery and another transnasal intervention. Also, the histological structure of the tumours needs to be taken into consideration when planning the approach and the extent of the surgical intervention. It is concluded that preliminary courses of chemo and radiotherapy do not significantly improve the outcome of surgical treatment; in contrast, they promote the development of complications during the postoperative period. The results of this study indicate that for the management of benign tumours characterized by the slow growth rate (osteoma, chondroma, chordoma) the traditional ENT approaches can be supplemented by transcranial surgery. Extensive interventions (anterior craniofacial reseaction, lateral craniofacial resection) are needed for the management of aggressive malignant tumours (ostesarcoma, chondrosarcoma) without serious injury the healthy tissues; moreover, such approach increases the survival rate of the patients.
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PMID:[Bone and cartilaginous tumours in the sino-paranasal region with intracranial extension. Peculiarities of surgical treatment]. 2371 81