Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chordomas are rare neoplasms of notochordal origin that arise along the vertebral axis. In the cervicofacial area, they show a marked proclivity for the sphenooccipital region. These slow-growing and infiltrating tumors are often discovered because of neglected symptoms related to the ENT field such as nasal obstruction, snoring, dyspnea or dysphagia in the case of anterior development, serous otitis media, cervical pain, or even palsy of the X, XI, or XII cranial nerves when the tumor develops toward the foramen jugulare or the foramen magnum. Prognosis is usually poor because of local malignancy, proximity to critical central nervous system structures, and volume of the tumor. Surgery is the preferred treatment for these extradural tumors, but most authors recommend postoperative irradiation because of surgical spillage or residual tumor. However, conventional irradiation is limited by the sensitivity of surrounding structures, which results in a poor rate of local control. We present 9 cases of histologically proven diagnosis of chordoma treated from 1984 to 1994 at our institution. Prognosis and therapeutic modalities are discussed. Therapeutic improvement might be brought the protontherapie, which ensures a better local control, and therefore may transform the prognosis of the disease.
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PMID:[Therapeutic management of craniocervical chordoma]. 876 68

Ventilation tubes (VTs) have been extensively used to treat chronic serous otitis media over the last 30 years. However, it is not known if this practice has affected the incidence of cholesteatoma. A retrospective study was carried out at two Regional ENT Centres in Northern Ireland, examining the clinical notes of all patients undergoing major ear surgery between 1965 and 1988. The incidence of cholesteatoma per operatively in this period varied from 0.01 to 0.16 per 1,000 of population per year. The total number of cholesteatomas in the first five years of the study was exactly equal to the number in the last five years, despite an eight-fold increase in VT insertion over this period. These results indicate that the incidence of cholesteatoma remained stable between 1965 and 1988 despite a huge increase in the use of VTs.
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PMID:Ventilation tubes and cholesteatoma. 899 53

Nasopharyngeal soft tissue is most commonly adenoid hypertrophy in children. Although rare, nasopharyngeal carcinoma (NPC) does occur in children. Nasal obstruction, serous otitis media, hearing problems, and tinnitus are common signs and symptoms of all nasal diseases. For this reason, the majority of NPC presents with advanced disease at the time of the diagnosis. This paper reported 7-year-old boy who was admitted to the hospital for adenoidectomy. He had recurrent adenoidectomy operation due to nasal obstruction. NPC had been diagnosed suspecting the hard mass in the nasopharynx during the operation. Adenoidectomy is the most commonly performed surgical procedure in ENT practice and NPC is unlikely to be considered in the differential diagnosis. Surgeon should be careful about signs and symptoms that alert suspicion.
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PMID:Diagnosis of pediatric nasopharynx carcinoma after recurrent adenoidectomy. 2439 36