Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three unusual cases of oropharyngeal lympho-proliferative lesions were seen in recipients of heart and heart-lung transplants. Two caused acute upper respiratory obstruction necessitating urgent ENT intervention. All patients were receiving immunosuppressive drugs including cyclosporin. The two obstructive cases were adenotonsillar enlargement in a 6-year-old, and a tumour of the tonsil and tongue base with cervical lymph node enlargement in a 32-year-old male. Both were caused by Epstein-Barr Virus-associated lymphoproliferative disorder. The third patient, a 32-year-old female, had a presumed low grade T-cell lymphoma that regressed spontaneously. Histopathological diagnosis of these lympho-proliferative disorders after transplantation usually requires immunocytochemistry to distinguish polyclonal proliferative disorders from true lymphoma. Polyclonal lymphoproliferative disorders after transplantation do not usually require aggressive cytoreductive therapy, but respond to simple measures such as the reduction of immunosuppression.
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PMID:Unusual lymphoproliferative oropharyngeal lesions in heart and heart-lung transplant recipients. 223 May 84

Nasal natural killer (NK)/T-cell lymphoma is an uncommon disease, and only a few paediatric cases are found in the literature. We report 2 cases of NK/T-cell lymphoma occurring in children. The primary site was the the nasal cavity in the first case (5-year-old girl) and the tonsil in the second case (4-year-old boy). Histological study showed a polymorphic neoplastic infiltrate with an angioinvasive pattern and T-cell phenotype. Ebstein-barr virus infection was established by in situ hybridization. Both underwent an aggressive chemotherapy regimen. The outcome was favorable for the 4-year old boy; however, the 5-year-old girl died two months after diagnosis.
B-ENT 2009
PMID:Nasal NK/T-cell lymphoma in the paediatric population. Two case reports. 1967 Jun