Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cervical phlegmona is a rare occurrence associated with infections of the ENT region. Spreading of the infection can cause thrombophlebitis, mediastinitis and cardiac tamponade. Three recently treated patients are reported who showed serious complications due to harmless primary infections of the oral cavity, oropharynx or throat. The clinical course of the diseases with the sometimes difficult examinations undertaken and the performed treatment are outlined. Computed tomography and radiography of the lung were useful in confirming the diagnosis, establishing that the infection had spread into deep neck spaces and into the mediastinum. Surgical therapy including extensive surgical drainage of the deep neck spaces and of the mediastinum, multiple antibiotic therapy, and intensive care, resulted in survival of the patients.
 ...
PMID:[Rare complications of soft tissue infections in the head and neck area: deep neck phlegmona, thrombophlebitis and mediastinitis with pericardial effusion]. 801 Oct 31

152 patients were admitted to the ENT hospital with the diagnosis thrombophlebitis of the sygmoid sinus (62.1% of the total number of the admitted patients with otogenic intracranial complications). The surgery was made early upon the admission. The authors advocate radical removal of the thrombus before, the start of hemorrhage from both sinus parts. In case of the absence of low hemorrhage the intervention on the internal jugular vein was decided on day 1-3 after the basic surgery depending on the clinical course. It is thought that in postoperative period antibiotic therapy should be supplemented with immune preparations made of donor blood, UV radiation of autoblood and hyperbaric oxygenation.
 ...
PMID:[Treatment policy in thrombophlebitis lesions of the sigmoid sinus and internal jugular vein during intensive use of antibiotics]. 1151 51

Sphenoid fungal balls are rare and typically indolent lesions, unless superinfected by bacteria or invasive to adjacent neurovascular structures. If the identification or treatment of underlying complications is delayed in an immunocompromised patient, a catastrophic outcome may result. We report the case of an elderly female patient with poorly controlled diabetes mellitus suffering from sphenoid fungal sinusitis that is complicated by cavernous sinus thrombophlebitis and carotid artery stenosis. In spite of reasonable diagnosis and therapy, the patient's general condition deteriorated and she eventually died. The clinical presentation, diagnosis, and treatment strategy are discussed.
B-ENT 2009
PMID:Lethal sphenoid fungal sinusitis in an immunocompromised elderly patient. 1990 55

Sinonasal and temporal bone infections may extend to the skull, skull base, meninges, pericerebral spaces, brain parenchyma, dural sinuses, deep cerebral or cortical veins, intracranial arteries and cranial nerves either via contiguous or hematogeneous spread. The site of infection dictates the sites of potential complications: orbital with ethmoid sinusitis, cavernous sinus thrombophlebitis and oculomotor palsies with sphenoid sinusitis, transverse sinus thrombophlebitis with mastoiditis and superior sagittal sinus thrombophlebitis with frontal sinusitis. All may result in brain abscess. Congenital and acquired defects of the skull and meninges, with or without associated meningocele or meningoencephalocele, perilymphatic fistulas, and some anomalies of the inner ear may predispose to the intracranial extension of ENT infections.
 ...
PMID:[Intracranial complications from ENT infections]. 2209 48

We report a case of Internal Jugular Vein Thrombosis with a long segment thrombus in a clinical setting of attico antral type of Chronic Suppurative Otitis Media (CSOM) in a 20 year male. He presented with hectic rise of temperature with chills & rigor of 7 days duration associated with left ear discharge & throbbing headache of 10 days duration. ENT examination revealed attico antral type of Chronic suppurative Otitis Media with sinus thrombophlebitis. Further investigations revealed a mural thrombus extending from the lower part of Internal Jugular Vein (IJV) till the Torcula Herophili. Left Modified radical mastoidectomy with exposure of transverse & sigmoid sinus was done to completely eradicate the disease and source of infection. The patient was treated with oral anticoagulants and parenteral antibiotics based on the sensitivity report and became asymptomatic after 8 weeks.
 ...
PMID:Internal jugular vein thrombosis in a case of attico antral disease - a rare presentation in this modern antibiotic era. 2312 May 5

Nowadays suppurative complications of sinusitis are uncommon in orderto widespread treatment with antibiotics. Intracranial complications include bacterial meningitis, encephalitis, brain abscess, epidural or subdural abscess and sinus thrombophlebitis.The 13-40% of all brain abscesses are sinogenic complications. The inflammation process spreads from sinuses by valveless diploic veins of the skull as thrombophlebitis or by direct extension of osteomyelitis. Jatrogenic, posttraumatic or natural fissures in bony walls can also take part in spreading the infection. Diagnostic process includes laryngological and neurological evaluation with the computer tomography scanning or magnetic resonance imaging. Patients with intracranial complications require broad-spectrum antibiotic therapy and surgical treatment in orderto remove the origin of infection in the sinuses. For physicians they are always challenging conditions according to their significantly high mortality. The case of the 24 year old patient with sinogenic brain abscess was shown in this paper. He neglected ambulatory treatment of chronic sinusitis because of lack of the medical insurance. After episode of losing the consciousness he was admitted to the ENT Department with headache, nausea, fever and dehydration. The diagnose was established based on laryngological and neurological examination and visualization of brain abscess on CT scans. He was treated by surgical intervention conducted by team of head and neck surgeons and neurosurgeons. Intensive antibiotic therapy with the Uffenorde operation of frontal sinuses and neurosurgical removal of the brain abscess was performed.The epidemiology, clinical course, diagnostic problems and therapy were described.
 ...
PMID:[A case of subclinical frontal lobe abscess as a complication of sinusitis]. 2577 20