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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirteen cases of sarcoidosis were seen at the Royal National Throat, Nose and Ear Hospital and St George's Hospital, Tooting, between 1963 and 1984 inclusive. In only 5 patients had a diagnosis of sarcoidosis been made prior to attendance. In the remaining 8 patients, there was a considerable delay in making a diagnosis in those cases with predominantly nasal symptoms, ranging from 8 to 18 months. Several patients with nasal sarcoidosis had evidence of systemic disease on investigation, but did not receive appropriate treatment early in the course of their disease because of the delay in initial diagnosis. Both the ENT surgeon and the general practitioner must be aware that symptoms of nasal obstruction, rhinorrhea and crusting are not always due to an allergic or vasomotor rhinitis, and granulomatous conditions should always be considered in the differential diagnosis of patients with these symptoms.
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PMID:Sarcoidosis in ENT practice. 384 52

In a brief review, the clinical aspect of sarcoidosis is presented and illustrated by 13 patients whose disease was discovered by its initial manifestation in the ENT region. An isolated sarcoidosis prevailed without general symptoms. The modification of the therapeutic concepts in the last years is demonstrated based on own cases; it changed from the continuous corticosteroid therapy to a more expectant and observant attitude.
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PMID:[Significance of the diagnosis of sarcoidosis in otorhinolaryngology]. 392 94

Isolated sarcoidosis is quite rare, causing non-specific symptoms and possibly not diagnosed because of the large number of other entities with similar presentations. We report the problems of diagnosis of isolated laryngeal sarcoidosis following a localized carcinoma. A 66-year-old patient was seen in the Westpfalz ENT Department after a Le Roux-Robert fronto-latera laryngeal resection for a pT1a N0 M0 vocal cord carcinoma following progressue dyspnea. Laryngoscopy showed laryngeal stenosis due to a neoplastic lesion. However, an epitheloid granulomatosis was found on histopathology with no evidence for recurrent carcinoma. After exclusion of other processes and systemic disease, the diagnosis of isolated laryngeal sarcoidosis was made and long-term corticoid medication was administered, resulting in a rapid regression of the laryngeal stenosis.
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PMID:[Coincidence of isolated laryngeal sarcoidosis and laryngeal carcinoma]. 953 61

Sarcoidosis is a systemic chronic granulomatous condition of unknown aetiology. Although the mediastino-pulmonary type is the commonest, the condition may affect the head and neck in a significant number of cases, obliging the practising ENT surgeon to be familiar with the condition. The diagnosis is made by a combination of clinical, biochemical, radiological and histopathological features. We present 10 cases of sarcoidosis with exclusively cervico-facial features which have passed through the department between 1985 and 1996, including a typical nasal case with combined features, and a very rare pharyngeal case. The definitive diagnosis, always with histological confirmation, was sometimes made only after some delay, demonstrating the polymorphic nature of the clinical features, which are rarely pathognomonic. Special investigations, carried out virtually routinely once the diagnosis of ENT sarcoidosis was made, demonstrated only one case of associated pulmonary disease. Treatment was reserved for the symptomatic cases (4 out of 10), and consisted of systemic steroids whose dose and duration was determined by the clinical response.
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PMID:[Otolaryngological manifestations of sarcoidosis. Report of 10 cases and review of the literature]. 977 39

Data are available on 14 patients with sarcoidosis of the face and upper respiratory tracts (11 females and 4 males, age from 29 to 71 years). 4 patients had isolated ENT lesion. In 3 cases, sarcoidosis was found at histological examination of the material removed in the course of surgery for chronic tonsillitis, recurrent purulent cyst, pyopolypous maxilloethmoiditis. Pain at the site of skin and mucosa affection was minor, ulceration was absent. Standard treatment was effective. 12 patients were followed up for 3 to 15 years. Good results were achieved in 2 patients, the rest were cured with a picture of mucosal atrophy in the lesion zone.
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PMID:[Sarcoidosis of face and upper respiratory tracts]. 1076 18

Imaging plays an important role in identifying thoracic, abdominal and neurological localizations of sarcoidosis as well as ENT and bone localizations. It contributes to disease detection and is helpful for diagnostic, prognostic and therapeutic decision making and useful for therapeutic monitoring. The chest x-ray is particularly important in the initial work-up and to follow well-tolerated disease. Other investigations, depending on the localization, are helpful to follow the course of severe or chronic sarcoidosis.
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PMID:[Value of imaging in sarcoidosis]. 1124 Apr 25

Mediastinal nodes evidenced in a patient referred for an expert opinion concerning an occupational disease were found to have a sarcoid-like character. The patient was a former smoker who had been exposed to asbestos for 27 years. The patient also had an ENT neoplasia. The nodal enlargements evidenced at mediastinoscopy were the only manifestations compatible with sarcoidosis, a rare association recognized in asbestosis.
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PMID:[Asbestosis and sarcoid-like thoracic lesions: a case report]. 1137 1

The primary ANCA associated vasculitides, Wegener's granulomatosis (WG), Churg Strauss syndrome (CSS) and microscopic polyangiitis (MPA), frequently affect the ENT region. For several reasons WG is of special significance for the otorhinolaryngologist. First, disease activity limited to the upper respiratory tract (localized WG) often proceeds the systemic vasculitis (generalized WG). The early diagnosis therefore has decisive consequences for stage adapted therapy. Second, in most cases (nearly 80%) WG is diagnosed histologically on biopsy specimens from the ENT region. During the initial phase of WG this is of diagnostic relevance, because at this stage the serologic parameters (acute-phase proteins) usually have a normal value and PR3-ANCA is (still) negative in 2/3 of the patients. Third, in many cases recurrences reveal increased activity in the ENT region, or start in this area. Clinically in most cases chronic rhinosinusitis with crusting and epistaxis is seen, sometimes with septal perforation and/or saddle nose. Apart from this there are often unclear middle ear symptoms with recurrent effusions and the inner ear is sometimes also affected. Laryngeal manifestations are typically located in the subglottic area and lead to subglottic stenosis. In the differential diagnosis, diseases in which epitheloid cell granulomas occur, such as sarcoidosis and TBC, need to be considered, but also foreign body granulomas and fungus diseases. Finally malignant tumours, especially malignant lymphomas, have to be ruled out.
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PMID:[Manifestations of primary vasculitis in the ENT region]. 1158 19

Sarcoidosis is a disease affecting the reticulo-histiocytary system and characterized by its several manifestations, always linked to the same lesion: the epithelioid granuloma without caseous necrosis. We make a review of this disease so scarce in our consulting rooms, and consider all patients diagnosed in our Hospital during one year-term, with their manifestations in ENT-area as well in other specialties and compare our inventory with other published series.
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PMID:[Sarcoidosis in otorhinolaryngology]. 1169 25

The aim of the study was to investigate the upper respiratory tract as a site of extrapulmonary sarcoidosis. Diagnosis of sarcoidosis with upper respiratory tract involvement was performed on the basis of clinical, laboratory, radiographic and histological evidence and by excluding other granulomatous diseases in eight patients followed by the Sarcoidosis Regional Reference Centre pneumologists in collaboration with an experienced ENT specialist at Siena University. In five cases, sarcoidosis was localized in the parotid glands, in the other three subjects larynx, nasopharynx and nose were involved. In four patients parotid gland, nasopharynx and upper respiratory tract mucous membrane involvement was the only clinical manifestation at onset of the disease. Upper respiratory tract involvement should be suspected in all patients with systemic sarcoidosis and in patients with persistent upper respiratory tract symptoms of unknown cause. What a general practitioner should do as not to miss SURT is underlined. Interdisciplinary management and collaboration are of paramount importance for rapid diagnosis and to avoid the possible complications of this form.
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PMID:Sarcoidosis with upper respiratory tract involvement. 1593 95


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