Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

78 cases of retinoblastoma (Rb) diagnosed at the Eye ENT Hospital, Shanghai from 1953 to 1985 were studied. The results of multiple Logistic regression analysis and conditional probability model showed that high fetal order had a moderate risk (OR = 1.28, P less than 0.05) of developing unilateral Rb. Both unilateral and bilateral cases were independent of parental ages, and no interaction could be found between fetal order and paternal or maternal age; also, the effect of fetal order was not confounded by paternal ages.
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PMID:[An analysis of effects of fetal order and parental age on retinoblastoma]. 262 39

A worldwide rise in the incidence of oropharyngeal squamous cell cancer has been recorded over the past decade. This rise has been attributed to an increase in oncogenic human papilloma virus (HPV) infections. The biology of HPV-positive oropharyngeal cancer is distinct; it includes p53 degradation, retinoblastoma pathway inactivation, and p16 upregulation. The best method for detecting HPV in tumour material is controversial; both in-situ hybridisation and PCR are commonly used. However, p16 can serve as a potential surrogate marker, and therefore, p16 immunohistochemistry is widely used in clinical practice. Compared to HPV-negative cancers, HPV-positive oropharyngeal cancer appears to be more responsive to chemotherapy and radiotherapy. Thus, p16 can serve as a prognostic marker for enhanced overall survival and disease-free survival. In this review, we aimed to highlight the current understanding of the epidemiology, biology, detection, and management of HPV-related oropharyngeal head and neck squamous cell carcinoma.
B-ENT 2015
PMID:HPV-positive head and neck tumours, a distinct clinical entity. 2656 6