Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0262471 (ENT)
 5,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between the years 1960 and 1981, 21 patients with the diagnosis of carcinoma in situ of the vocal cords were treated in the ENT department of Beilinson Medical Center. All 21 patients received initial irradiation therapy, identical to patients with invasive squamous cell carcinoma--7200 rads Co60 tumour dose. No patient died as a result of tumour. One patient had local recurrence of invasive carcinoma after 3 years and subsequently underwent total laryngectomy. One patient died after 15 years as a result of myocardial infarction. It is important to mention that 20 patients (95.2%) were free of tumour during a follow-up of 4-25 years (mean 11 years). This study shows that radiotherapy is a highly effective method of management for carcinoma in situ of the glottic region.
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PMID:Carcinoma in situ of the vocal cords: a retrospective study. 340 2

Minimal intraoperative bleeding, the advantage of precise cutting under microscopic control, and the near total absence of postoperative edema make the CO2-laser particularly suited for endolaryngeal surgery. Between October 1978 and July 1982, 22 patients with early carcinoma of the larynx (8 carcinoma in situ, 2 verrucous carcinoma, 12 T1 true vocal cord carcinoma) have undergone endolaryngeal resection with the CO2-laser at the ENT-Department of the University Hospital of Zurich. All patients were hospitalized for three to four days. None of them needed a tracheostomy. Follow-up ranges from three month to four years (average 17 months). So far there have been no recurrences. The quality of the postoperative voice varies from poor to fairly good, depending on the extent of the resection and on the amount of scarring. Compared to conventional chordectomy via laryngofissure, which necessitates tracheostomy, endolaryngeal laser-chordectomie is tolerated better and more cost-effective. Recurrences after endolaryngeal laser-chordectomy are still amenable to voice-saving radiation therapy.
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PMID:[Initial experiences with endolaryngeal CO2-laser surgery in circumscribed laryngeal cancer]. 668 1

A questionnaire has been distributed among ENT physicians in Russia and CIS on their approaches to management of paratonsillitis with reference to the disease stage. Many respondents approve active surgical policy and on demand perform abscesstonsillectomy in acute period. Those who perform the operations in "hot", "warm" and "cold" period fall into approximately equal groups.
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PMID:[Paratonsillitis: aspects of therapeutic policy]. 1038 Jun 3

Schneiderian papillomas are uncommon benign tumors of the sinonasal area. They are prone to local aggressiveness and recurrence, and some undergo malignant progression. We analyzed specimens obtained from 67 Chinese patients who had presented to the ENT department of a regional hospital with biopsy-proven schneiderian papilloma. Seven of these patients had either synchronous or metachronous carcinoma, 1 of whom had pure carcinoma in situ. For each case, we documented the morphology, immunohistochemical expression of tumor suppressor genes p53 and p16, and any association with human papillomavirus (HPV) infection as detected by either polymerase chain reaction or in situ hybridization techniques. We found that severe dysplasia and p53 positivity were strongly associated with malignant progression. Association with HPV was demonstrated in 22 of the 67 patients (33%); the association was strongest among patients with exophytic papillomas and carcinomas. The effect of HPV in papilloma oncogenesis probably begins during the early phase, while other factors are responsible for progression to carcinoma. We conclude that p53-positive, dysplastic schneiderian papillomas warrant aggressive surgical treatment.
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PMID:Schneiderian papillomas and carcinomas: a retrospective study with special reference to p53 and p16 tumor suppressor gene expression and association with HPV. 2098 55

Practical aspects of Storz Dlight autofluorescence bronchoscopy are presented from a series of 73 patients. 80 biopsies were taken of which 23 had at least moderate dysplasia, including 8 CIS lesions. Causes of false positive fluorescence abnormalities were suction trauma, overlying mucus, depressions in the leading edge of bronchial spurs, and flexion points of spurs. Positive predictive value of a significant fluorescence abnormality was 56%. The highest yield was in those patients with prior ENT malignancy.
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PMID:Practical issues in autofluorescence bronchoscopy with Storz D Light bronchoscope. 2504 39