Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0243026 (sepsis)
 52,417 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 3249
cytokine 3032
lipopolysaccharide 3012
IL-6 1671
LPS 1646
tumor necrosis factor 1564
TNF 1492
Mol 1245
Pseudomonas 1179
IL-10 887
C-reactive protein 840
gut 837
TLR4 814
TNF-alpha 709
She 698
interleukin-6 636
insulin 573
inducible nitric oxide synthase 547
albumin 526
IL-8 504
thrombin 470
nitric oxide synthase 423
myeloperoxidase 418
IL-1 375
tumor necrosis factor alpha 364
fibrinogen 346
CD14 332
protein C 330
CD4 323
hemoglobin 321
granulocyte 321
interferon 319
IFN 312
caspase-3 306
Cytokine 294
tissue factor 294
p38 282
chemokine 280
ATP 278
TLR2 253
prothrombin 244
lymphoid 232
antithrombin 226
superoxide dismutase 223
serum albumin 219
p65 218
CSF 211
interleukin 6 193
MAPK 191
MRI 191
CD11b 189
CRP 184
high mobility group box 1 180
collagen 179
vascular endothelium 179
granulocyte colony-stimulating factor 178
fibronectin 176
chronic renal failure 174
CD8 171
MyD88 168
IFN-gamma 167
muscle protein 167
glycoprotein 167
CLP 165
thrombomodulin 160
alanine aminotransferase 160
Bcl-2 158
Tumor necrosis factor 158
IL-1 beta 156
thromboplastin 156
catalase 156
MIC 156
vasopressin 156
aspartate aminotransferase 155
interferon-gamma 144
IL-2 144
IL-18 142
HLA 142
ICAM-1 141
interleukin-10 141
IgA 139
antithrombin III 138
IL-4 136
alkaline phosphatase 136
HMGB1 135
ubiquitin 131
HLA-DR 130
THP 128
MCP-1 127
histone 127
lactate dehydrogenase 126
DIC 124
proteasome 124
heme oxygenase-1 123
ERK 122
JNK 122
reserved 121
IL-17 119
SARS 118
ERK1 115
adhesion molecule 112
lactoferrin 110
NLRP3 110
cyclooxygenase 109
Pol 108
MRSA 106
plasminogen activator inhibitor-1 101
GBS 101
ROS 100
G-CSF 100
glucagon 100
GSH 100
PI3K 99
MIP 98
H. influenzae 98
thymus 95
transferrin 93
endoplasmic reticulum 92
PLA 92
ferritin 92
growth hormone 91
mTOR 90
glucan 90
CD64 89
STAT3 88
calcitonin 88
kit 87
E-selectin 87
renin 84
Protein C 84
tissue factor pathway inhibitor 84
macrophage migration inhibitory factor 83
vascular cell adhesion molecule-1 82
COX-2 82
plasminogen activator inhibitor 81
galactosamine 80
SOD 80
creatine kinase 80
non-Hodgkin's lymphoma 79
bradykinin 78
white cell 78
natriuretic peptide 78
CD18 77
serine protease 77
cyclooxygenase-2 77
LDH 77
interleukin-2 76
CO2 75
von Willebrand factor 75
C5a receptor 75
TOF 74
TPN 73
vascular endothelial growth factor 73
TLR9 73
mitogen-activated protein 72
CD25 72
granulocyte-macrophage colony-stimulating factor 71
E. coli) 71
ANOVA 70
intercellular adhesion molecule-1 70
more...
Disease
sepsis 52417
sepsis 52184
pneumonia 3068
cancer 2488
meningitis 1738
bacteremia 1598
peritonitis 1345
infectious diseases 1283
diabetes 1210
disseminated intravascular coagulation 1094
ischemia 1008
renal failure 944
tumor 919
Infection 841
bacterial infection 839
neutropenia 812
thrombocytopenia 789
endocarditis 758
acute renal failure 744
heart failure 731
respiratory failure 708
adult respiratory distress syndrome 706
Klebsiella 694
stroke 656
hypertension 637
anemia 571
urinary tract infection 559
coagulopathy 553
necrotizing enterocolitis 531
pancreatitis 522
cirrhosis 522
depression 515
malnutrition 446
encephalopathy 444
HIV 440
osteomyelitis 434
liver disease 433
leukemia 410
myocardial infarction 408
renal disease 406
acute pancreatitis 390
lymphoma 387
arthritis 383
rheumatoid arthritis 380
pulmonary edema 374
immunodeficiency 371
carcinoma 364
prematurity 344
tuberculosis 327
AIDS 326
Infections 306
Severe sepsis 305
acute myeloid leukemia 305
hepatitis 302
rash 291
abortion 289
Crohn's disease 288
cholangitis 287
obesity 285
pulmonary hypertension 284
pulmonary embolism 283
cellulitis 282
atherosclerosis 280
congestive heart failure 276
hypoglycemia 275
leukopenia 273
cholestasis 272
cytomegalovirus 269
systemic lupus erythematosus 264
Haemophilus 263
septic arthritis 255
SIRS 255
chronic renal failure 255
fasciitis 253
asthma 251
hyperglycemia 250
coma 249
chorioamnionitis 249
pyelonephritis 249
influenza 248
malaria 246
bowel obstruction 244
fungal infection 244
heart disease 244
cardiomyopathy 243
virus infection 239
graft-versus-host disease 234
vasculitis 232
dehydration 232
inflammatory bowel disease 229
endotoxic shock 229
metastases 228
hernia 227
gangrene 219
ARF 216
empyema 213
nosocomial infection 203
colitis 197
bacterial meningitis 196
bronchopulmonary dysplasia 190
hyperbilirubinemia 185
lung disease 185
chronic obstructive pulmonary disease 184
toxic shock syndrome 184
cardiovascular disease 178
preeclampsia 178
candidiasis 177
enterocolitis 174
mediastinitis 171
Neonatal sepsis 168
pneumothorax 167
agranulocytosis 166
renal insufficiency 166
ulcerative colitis 164
ileus 164
acute lymphoblastic leukemia 164
gastroenteritis 163
myelosuppression 163
gallstones 160
Hodgkin's disease 159
purpura 159
SARS 159
pancytopenia 158
cystic fibrosis 157
appendicitis 155
muscular atrophy 153
acute myocardial infarction 153
uterus 150
thrombophlebitis 149
lactic acidosis 147
adrenal insufficiency 147
adenocarcinoma 147
cholecystitis 147
deep vein thrombosis 146
MRSA 145
myocarditis 145
myocardial ischemia 142
Mycobacterium 142
cold 140
melioidosis 140
cognitive impairment 138
lymphadenopathy 133
Colon 132
sickle cell disease 132
Colon 132
Colon 132
acute leukemia 132
eclampsia 131
multiple myeloma 130
premature rupture of membranes 128
encephalitis 128
confusion 125
West 123
hepatocellular carcinoma 123
alcoholism 122
liver abscess 121
glomerulonephritis 121
hyperphagia 120
aggression 120
Proteus 120
more...
Symptom
respiratory distress 1354
pain 870
diarrhea 766
anesthesia 600
abdominal pain 445
vomiting 415
hypothermia 288
weakness 284
seizures 268
nausea 193
collapse 185
dyspnea 181
fatigue 157
headache 143
oliguria 139
lethargy 139
cachexia 133
splenomegaly 132
anorexia 131
chills 119
tachypnea 116
starvation 113
hepatosplenomegaly 103
nausea and vomiting 101
cough 99
analgesia 92
hepatomegaly 91
acute abdomen 90
Ill 90
erythema 85
discomfort 75
discomfort 74
chest pain 70
back pain 70
fever of unknown origin 70
exhaustion 63
sore throat 57
cyanosis 53
constipation 53
myalgia 48
hemoptysis 48
regurgitation 47
hyperoxia 46
hypercapnia 46
shortness of breath 43
arthralgia 42
colic 39
hypotonia 37
flank pain 34
functional recovery 34
sleepiness 32
syncope 32
epigastric pain 30
angina 29
pallor 28
acute abdominal pain 27
low back pain 26
rigors 25
hip pain 23
paresis 23
flushing 22
pelvic pain 22
ataxia 22
ENT 22
microbial colonization 21
polyuria 21
dizziness 21
hypoproteinemia 20
agitation 19
dysuria 19
neck pain 18
bone pain 17
acute stress 17
spasticity 17
acidity 17
overweight 16
productive cough 16
asthenia 15
tremor 15
right upper quadrant pain 15
intestinal bleeding 14
distraction 14
abdominal discomfort 14
tense 13
Wind 13
spasm 13
blurred vision 13
thigh pain 13
stridor 12
consciousness disturbance 12
numbness 11
adenitis 11
knee pain 11
paresthesia 11
paraparesis 11
neck stiffness 11
hoarseness 11
leg pain 11
renal colic 11
muscle rigidity 11
Organ failure 11
hypocapnia 10
wheezing 10
dysarthria 10
right lower quadrant pain 10
HSA 10
shoulder pain 10
myoclonus 10
chronic cough 9
tonic-clonic seizure 9
livedo 9
inanition 9
anal pain 9
ophthalmoplegia 8
chronic constipation 8
thinning 8
hypertonia 8
hemiplegia 7
meningism 7
exertional dyspnea 7
ketonuria 6
polydipsia 6
insomnia 6
rales 6
bloating 6
pneumaturia 6
decreased appetite 6
neurological disability 6
loin pain 6
apathy 6
retching 6
autodigestion 6
twitching 5
dark urine 5
skin irritation 5
nasal discharge 5
pleuritic chest pain 5
tinnitus 5
otalgia 5
facial pain 5
acute pain 5
night sweats 5
orthopnea 4
nipple discharge 4
dry skin 4
groin pain 4
abdominal cramps 4
left upper quadrant pain 4
Murphy's sign 4
leg edema 4
dystonia 4
stigma 4
prostration 4
rhinorrhea 4
presyncope 4
nipple discharge 4
muscle cramps 4
photophobia 4
memory loss 4
generalized rash 3
more...
Drug
ampicillin 391
Cardiovasc 369
CSF 260
Dermatol 206
IFN-gamma 164
IL-2 144
Dial 135
Monit 116
G-CSF 103
ROS 100
lysine 96
Nephron 93
ascorbate 92
ROC 90
CTX 77
MAP 68
CTX 63
CTX 63
Drotrecogin alfa 62
Drotrecogin alfa 62
IPM 56
Albumin 54
Bifidobacterium 46
Nephron 46
MOF 43
Heme 41
vitamin E 38
NADH 37
IL-1ra 35
Portal 31
ENT 31
Ringer's solution 30
lactose 30
Ceftazidime 28
Indomethacin 28
Piperacillin 27
p75 27
Simvastatin 25
Antithrombin III 24
TAK 24
Rituximab 23
Meropenem 23
SBT 22
Adriamycin 22
Propofol 21
Fraction 19
AMC 19
Nitric Oxide 19
caffeine 19
Meropenem 18
Gel 18
Serum albumin 18
Colistin 18
nitroglycerin 17
CPR 17
TAT 16
Taxol 16
Amoxicillin 16
Augmentin 16
Augmentin 16
Methylprednisolone 15
CPZ 15
Asthma 15
Fluconazole 15
Ulinastatin 15
Cimetidine 14
AZT 14
Cimetidine 14
Tacrolimus 13
Levosimendan 13
Growth hormone 13
Ethanol 13
Growth hormone 13
Aminoguanidine 12
MDS 12
Fluorescein 12
Glutathione 12
IFN-beta 12
Prednisolone 12
uPA 11
Alliance 11
Spectrum 11
Hypaque 11
Filgrastim 11
Docetaxel 10
Campath 10
Leaf 10
Parkin 10
Campath 10
DNase I 10
E5564 10
Parkin 10
CPT-11 10
Glucagon 10
citric acid 10
Filgrastim 10
CaCl2 9
Histamine 9
Ganciclovir 9
ICI 9
ADM 9
Methylene blue 9
Sulfamylon 9
Angiotensin II 8
Alanine 8
Doxycycline 8
Fructose 8
Ofloxacin 8
Infliximab 8
EPA 8
Lovastatin 8
Infliximab 8
ETA 8
PAPM/BP 8
ABC 8
Emodin 8
AmBisome 8
Diphenhydramine 7
Aprotinin 7
CCL 7
ALA 7
Caspofungin 7
Vitamin A 7
CaCl2 7
Vinorelbine 7
CaCl2 7
THA 7
MRC 7
Misoprostol 7
Survanta 7
Moxifloxacin 7
Zinat 7
Phosphatidylserine 7
DEX 6
Sivelestat 6
TTC 6
Emodin 6
PTH 6
balanced salt solution 6
Vicryl 6
Spectrum 6
ARA-C 6
Amiloride 6
Fluorescein 6
NovoSeven 6
Itraconazole 6
Centoxin 6
Hydroxyethylstarch 6
CAM 6
Azithromycin 6
Hypaque 6
Timentin 6
Vitamin E 6
IL-11 6
Sodium thiosulfate 5
PTC 5
CDP 5
Trimethoprim-sulfamethoxazole 5
BH4 5
NAG 5
more...
Enzyme
APC 672
mitogen-activated protein kinase 506
thrombin 460
peroxidase 454
alanine aminotransferase 326
superoxide dismutase 277
NO synthase 257
aspartate aminotransferase 226
caspase-3 220
ERK 193
catalase 177
thromboplastin 169
protein kinase 166
lactate dehydrogenase 153
beta-lactamase 142
caspase-1 137
alkaline phosphatase 136
focal adhesion kinase 134
proteasome 131
protein kinase C 122
elastase 117
NOS 114
luciferase 105
creatine kinase 101
MIP 98
NADPH oxidase 96
NADPH oxidase 88
plasmin 86
renin 84
neutrophil elastase 82
AMP-activated protein kinase 77
phospholipase A2 75
tissue plasminogen activator 74
ATPase 71
kallikrein 66
AST 66
glutathione peroxidase 66
MAP 65
phosphodiesterase 60
heme oxygenase 57
reverse transcriptase 54
ACS 53
urokinase-type plasminogen activator 52
lysozyme 52
ACE 51
trypsin 50
IKK 49
caspase-11 47
caspase-11 47
complex I 46
phospholipase C 46
collagenase 46
guanylate cyclase 46
xanthine oxidase 46
neuraminidase 43
PARP 41
phosphatidylinositol 3-kinase 41
AMPK 38
calcineurin 37
lipase 36
AMPK 35
caspase-8 35
pyruvate dehydrogenase 34
BMT 33
MEK 32
acetylcholinesterase 31
caspase-9 29
succinate dehydrogenase 28
RNA polymerase 28
GSK 27
CD10 27
phosphoinositide 3-kinase 26
cytochrome oxidase 26
lipoxygenase 25
DNase 25
gamma-glutamyl transpeptidase 25
asparaginase 25
glucose-6-phosphate dehydrogenase 24
myosin light chain kinase 23
RNase 22
lipoprotein lipase 22
transcriptase 22
cathepsin G 21
arginase 20
RNase 20
PDK1 20
cholinesterase 20
CPR 19
pyruvate dehydrogenase 19
pyruvate dehydrogenase 19
cathepsin B 18
CPT 18
caspase-4 18
caspase-4 18
GRK5 17
glutaminase 17
adenylate cyclase 17
glutamine synthetase 16
TAT 16
matrix metalloproteinase 9 16
BAL 15
urease 15
PKG 15
urease 15
ceruloplasmin 15
beta-glucuronidase 14
thrombin-activatable fibrinolysis inhibitor 14
GAS 14
diamine oxidase 14
hyaluronidase 13
peptidylarginine deiminase 12
hyaluronidase 12
p100 12
deoxyribonuclease 12
phosphoenolpyruvate carboxykinase 12
deoxyribonuclease 12
sialidase 11
MDR 11
acid phosphatase 11
adenosine deaminase 11
angiotensin-converting enzyme 2 11
adenosine deaminase 11
phosphoenolpyruvate carboxykinase 11
prostate-specific antigen 11
phosphoenolpyruvate carboxykinase 11
granzyme B 11
ornithine transcarbamylase 10
P-glycoprotein 10
meprin 10
citrate synthase 10
lysin 10
indoleamine 2,3-dioxygenase 9
NQO1 9
pyruvate kinase 9
ornithine decarboxylase 9
ScpA 9
CD13 9
ATP synthase 9
endonuclease 9
topoisomerase 9
thromboxane synthase 8
CPT 8
CaMKII 8
C3 convertase 8
chymotrypsin 8
mu-calpain 8
m-calpain 8
CPT 8
peroxiredoxin 8
hexokinase 8
topoisomerase 8
aldose reductase 8
glyceraldehyde-3-phosphate dehydrogenase 8
phosphorylase 8
glutamate dehydrogenase 7
enolase 7
paraoxonase 7
glutamate dehydrogenase 7
DNA polymerase 7
TACE 7
more...
Compound
Clin 4413
Dec 3483
oxygen 2023
TNF 1492
nitric oxide 1161
DNA 1031
glucose 932
creatinine 892
water 705
calcium 580
nitrogen 559
sodium 558
urea 455
arginine 421
iron 323
His 320
phosphate 307
Cardiol 286
ATP 278
glutamine 246
CO2 239
tyrosine 218
nitrate 192
galactose 189
sulfate 187
leucine 186
acetate 183
alanine 164
potassium 161
Phe 158
hydrogen 157
MIC 156
serine 139
zinc 138
Dial 135
DIC 134
lysine 133
THP 128
THP 128
ethanol 119
Methicillin 117
cysteine 116
prostacyclin 110
GSH 109
GSH 109
Parenteral 108
silver 102
Vancomycin 99
iodine 98
cAMP 98
Optimal 94
noradrenaline 87
PGE2 82
methionine 80
ADP 80
Insulin 79
CTX 77
ammonia 77
NADP 77
vitamin D 76
salt 75
N-acetylcysteine 74
TOF 74
PEG 72
Lactate 71
cGMP 71
glutamate 69
ADP 67
MAP 67
barium 65
ADP 64
ACTH 64
Glutamine 63
valine 62
Melatonin 61
tryptophan 61
tryptophan 61
glycerol 60
threonine 60
H2S 59
tryptophan 59
Ile 59
tryptophan 59
PEG 57
GPT 56
NAD 56
H2O2 54
ACS 53
ACS 53
Penicillin 53
3-methylhistidine 53
copper 52
nicotinamide 52
PGE 51
selenium 51
aldosterone 50
Pentoxifylline 49
Gentamicin 48
SDS 48
BRL 48
Guo 48
EDTA 48
phosphorus 47
Thrombin 47
Guo 47
EDTA 46
isoleucine 45
neopterin 45
Penicillin 45
isoleucine 44
Heme 44
Heparin 44
dUTP 43
Norepinephrine 43
proline 43
ASA 42
Imipenem 41
AMP 41
NH2 41
MDA 40
TEM 38
Ascorbic acid 38
A 3 37
NAD 37
Asp 37
sodium chloride 37
Hematoxylin 37
NADH 37
VP-16 37
5-FU 36
Amphotericin B 36
BCG 36
Gly 36
Dexamethasone 35
GMP 35
NO3 35
Adrenal 34
MTT 34
ammonium 34
FK506 34
Ciprofloxacin 33
DMSO 33
NIDA 33
Vasopressin 33
prostaglandin E1 33
superoxide radical 32
Adriamycin 32
PMA 32
Polymyxin B 31
Adenosine 31
Cortisol 31
Ceftriaxone 31
CAT 31
Angiotensin II 30
Amikacin 30
PMA 30
manganese 30
6-12 29
carbonate 29
Hemoglobin 29
more...