Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0243026 (
sepsis
)
52,417
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Bacterial infection is a serious public health issue because this may cause bacterial pneumonia and bacteria-infected
sepsis
. The conventional antibiotic therapy can cause bacterial resistance and other adverse effects. Herein, we designed a novel photoresponsive hybrid, in which MoS
2
nanosheets were doped with copper ions (MoS
2
@Cu
2+
). This system can effectively kill bacteria under 660 nm visible light irradiation due to enhanced photocatalytic and photothermal performances. The underlying mechanism is that when doping copper ions in MoS
2
, the photogenerated electrons can be rapidly transferred from the conduction band of MoS
2
to copper ions, consequently reducing the electron-
hole
recombination, thereby enhancing the yield of radical oxygen species (ROS). Besides the intrinsic photothermal performance of MoS
2
, the Cu
2+
ion can absorb photons and transfer the photoenergy into heat due to the d-d transition of electrons, resulting in enhanced photothermal properties of MoS
2
@Cu
2+
compared with pristine MoS
2
. Therefore, owing to the synergistic action of hyperthermia, ROS and released Cu
2+
, this system exhibited highly effective antibacterial efficacy when exposed to 660 nm light for 20 min, i.e., 99.64% against Staphylococcus aureus. The cytotoxicity test showed that the synthesized MoS
2
@Cu
2+
had good biocompatibility. This system will be a potential platform for environmental disinfection, healing of bacteria-infected wounds and other rapid bacteria-killing fields.
...
PMID:The rapid photoresponsive bacteria-killing of Cu-doped MoS
2
. 3257 88
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