Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0243026 (sepsis)
 52,417 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Abdominal aortic aneurysm surgery (AAA) is associated with perturbations of immune response and decreased immunity to infection, followed by high risk of organ and systemic complications development, including sepsis. The postoperative mortality in patients with AAA comes up to 10-12% and determines us to look for factors that may influence the immune response and are important for uneventful postoperative course. IL-12 is a potent immunoregulatory cytokine, that regulates cellular and humoral immunity. The aim of this study was to determine the IL-12 serum level in patients with AAA and its relation to ischaemia and reperfusion during aortic surgery. The study comprised 17 patients undergoing AAA repair and 10 patients of control group. Peripheral blood samples were taken before surgery (T0), before unclamping of aorta (T1), 90 minutes after unclamping (T2) and 24 h after surgery (T3). The IL-12 serum concentrations were measured with high sensitivity ELISA technique. IL-12 serum concentration was significantly higher in patients with AAA than in control group. During surgery a slight elevation after ischaemia (T1) and great depletion after reperfusion (T2) were observed. We found a significant correlation between IL-12 level at T2 and the length of surgery. The serum level of IL-12 is higher in AAA patients than in healthy men. Ischaemia and reperfusion during AAA repair results in an increase followed by decrease of cytokine serum level. There was not relationship between IL-12 level and its changes and postoperative course of AAA patients.
Pol Arch Med Wewn 2004 Oct
PMID:[Serum concentration of interleukin-12 (IL-12) in patients undergoing abdominal aortic aneurysm repair--preliminary report]. 1577 29

A case of Group B Streptococcus sepsis is reported in a male newborn with a renal vascular hypertension. An abdominal Doppler examination revealed aortic thrombosis extending from renal to the common iliac arteries. Prolonged broad spectrum antibiotic therapy and fibrinolytic treatment combined with surgical thrombectomy were used, at last obtaining improvement of general patient condition. The infant's hypertension resolved and reperfusion of the right kidney and urine output resumed. Ultrasound examination at 4th month showed presence of collateral circulation to arteries providing right lower limb. Patient's long-term out come is still under control of Outpatient Department of Vascular Surgery.
Ginekol Pol 2005 Jan
PMID:[Abdominal aortic-iliac thrombosis as a complication of newborn's bacterial sepsis]. 1584 68

Intraamniotic infection has been recognized as a major etiologic factor for preterm delivery. Several groups have proposed that amniocentesis be used to identify the patient at risk for infectious morbidity. The number of techniques have been studied for rapid identification of bacterial colonization of amniotic cavity. Diagnostic index value of Gram stain, white blood cell count, glucose level and LDH (lactate dehydrogenase) activity for prediction of positive amniotic fluid culture, preterm delivery, clinical infection and neonatal sepsis were shown in the study. Investigators continue attempts to establish a rapid, more useful tests to predict preterm delivery.
Ginekol Pol 2005 Jan
PMID:[Amniotic fluid analysis. Part I: Rapid markers in the prediction of intra-amniotic infection]. 1584 71

One of possible and diagnostically difficult sources of bacterial sepsis may be purulent foci of odontogenic character. We present the case of a pregnant woman, in whom untreated purulent focus within oral cavity led to severe systemic infection. The disease was characterized by persistent hectic fever with accompanying features of intravascular coagulation, anemia and erythema nodosum and no response to antibiotic treatment. It was the second episode of sepsis in this patient in a period of one year, the source of the infectious process not being recognized previously. Dental examination revealed presence of the apical abscess of the tooth 6-, extraction of which led to spectacular clinical improvement, accompanied by the healing of erythema nodosum. The clinical course and outcome of the disease strongly supports odontogenic etiology, in spite of the lack of full microbiological confirmation. Purulent foci within oral cavity, including apical abscesses, constitute significant clinical problem and must be taken into consideration as a potential source of severe and recurrent systemic infections.
Pol Merkur Lekarski 2005 Mar
PMID:[Severe form of odontogenic sepsis--a case report]. 1599 41

An incidence of sepsis, septic shock, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) is still actual clinical problem. Inducing factors and clinical pictures are similar to recently reported data from comparable populations in North America, Europe and Australia. The most important complication of severe sepsis is organ dysfunction observed in over 30% of sepsis patients hospitalized in intensive care unit. Applied intensive therapy including new generations of antibiotics gives an increase in clinical recovery. However, a hospital mortality of sepsis patients is over 30%.
Pol Merkur Lekarski 2006 Feb
PMID:[Sepsis--actual clinical problem]. 1670 53

Descending necrotic mediastinitis is a serious illness which, among others, follows acute bacterial infections located in a cervical area. One of the most frequent causes of this illness, not connected with surgical interventions, is a peritonsillar and peridental abscess. The process originally placed in the peritonsillar area spreads along the cervical fascia engulfs mediastinum. Inflammatory process of the mediastinum considerably worsens the prognosis and obligates to decisive surgical (mediastinum drainage) and pharmacological (antibiotic therapy) treatments. The following works presents the course of the illness of a 55-year-old man who was diagnosed with severe sepsis in the course of the peritonsillar abscess. After surgical provision of the abscess (incision) the patient was qualified for the therapy with activated protein C (Xigris, Lilly). The patient condition initially improved, however, after 8 days a descending necrotic mediastinitis with ambilateral pleural abscess was diagnosed. The administration of the treatment within 48 days of hospitalization (antibiotic therapy, thoracotomy, flow drainage of the mediastinum, tracheotomy, respirotherapy) brought about the effect of complete recovery.
Otolaryngol Pol 2006
PMID:[Severe sepsis as a complication of descending necrotizing mediastinitis due to a peritonsillar abscess. A case study]. 1690 40

Each factor infection or non-infection (surgery, burn) can be the cause of inflammatory reaction development and in turn releasing of pro- and antiinflammatory mediators. Excessive or/and uncontrol releasing of these mediators leads to endothelium damage and organ dysfunction. Standard analysis of common infection markers, i.e. peripheral blood leukocytes, C-reactive protein, reaction of Biernacki measurements, do not allow to distinguish infection and noninfection reason of systemic inflammatory response. Procalcitonin is the specific marker for bacterial and fungal infection. Its level is low during local bacterial and virus infection, autoimmunological diseases, but it is increased at the patients with sepsis, severe sepsis. In described case (patient with Wegener's granulomatosis) applying procalcitonin measurement and sensitive and specific microbiological diagnostic by using bronchio-alveolal lavage leads to successful treatment.
Pol Merkur Lekarski 2006 Oct
PMID:[Severe sepsis or clinical view of autoaggressive disease. Wegener's granulomatosis--case report]. 1720 75

Endoscopic sphincterotomy and stone extraction has become method of choice in the treatment of residual lithiasis after cholecystectomy. Then safe endeavour and effective, yet despite many advantages possible complications are. The paper presents a rare case endoscopic sphincterotomy under form of gigantic abscess of extraperitoneal space from consequent sepsis and death of patient.
Pol Merkur Lekarski 2007 May
PMID:[Late complication of endoscopic sphincterotomy]. 1767 84

The Yersinia genus belongs to the Enterobacteriacae family and comprises strains pathogenic for humans, which causes diseases of the gastrointestinal system. The infection can be transmitted with blood and blood components causing sepsis. The paper presents Yersinia enterocolitica complications after transfusion of blood and blood components as well as the frequency of occurrence and preventive measures.
Pol Merkur Lekarski 2007 May
PMID:[Infections of the gastrointestinal system--risk of transmission with blood and blood components]. 1767 6

Hyper IgE syndrome (Job's syndrome) is a rare multiorgan disease characterized by the triad: elevated serum IgE level, recurrent sinopulmonary infections, most often staphylococcal, and cutaneous cold abscesses starting in infancy. We report 21 years old patient with hyper IgE syndrome, diagnosed at age of 6 years on the basis of hyperimmunoglobulinaemia E and recurrent pulmonary and cutaneous infections. Now he was admitted because of pneumonia complicating with pneumatocele, which could not be resolved despite intravenous antibiotics. Surgical intervention was necessary. The postoperative period was complicated by Staphyloccocus aureus sepsis.
Pneumonol Alergol Pol 2007
PMID:[Pneumatocele during long-lasting observation of hyper IgE patient]. 1797 30


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>