Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0243026 (sepsis)
 52,417 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During 1985 and December 1990 children referred to hospitals with HIV infection were subjected to a protocol previously established to determine HIV antibodies by ELISA and Western Blot methods. Children under 15 months of age underwent repeated tests to preclude the transfer of maternal antibodies. In this group only children with more than 6 months of follow-up were included. 17 cases were studied: 6 were children under 15 months of age, 8 were between 15 months and 5 years, and 3 were between 5 years and 15 years. 12 children originated from urban areas, 3 from rural areas, and 2 were foreigners. The clinical symptoms started in the first year of life in 8 cases, between 1 and 3 years in 7 cases, and after 5 years of age in 2 cases. HIV transmission was vertical in 8 cases, via blood transfusion in 2 cases, and in 7 cases the route of transmission could not be confirmed. The follow-up lasted 6 months for 5 cases; 18 months for 5 cases; 2 years for 4 cases; and 3.5 years for 3 cases. The clinical signs were predominantly: cutaneous lesions in 10 of the 17 cases, diarrheal disease in 7, fever in 6, malnutrition in 6, as well as hypertrophy, oral moniliasis, sepsis, esophageal candidiasis, otitis, and varicella in different patients. According to CDC classification, 9 cases corresponded to class P-1 (one of them with elevated immune function and the other with normal immune function); 6 corresponded to pediatric class P-2 (2 to subclass A, 2 to subclass D, and 2 to subclass D-2). 6 children died: 4 due to meningitis and sepsis, 1 due to varicella, and 1 due to malnutrition, sepsis, and esophageal candidiasis.
Arch Domin Pediatr
PMID:[Pediatric AIDS: characteristics of 17 Dominican cases]. 1234 59

The archives of the blood bank of the hospital of Dr. Louis Manual Morillo King, in the city of La Vega, Dominican Republic, were reviewed to identify all children who had been given blood transfusion during the period of July 1983 to July 1987 in order to identify HIV and the surface antigen of hepatitis B (HBsAg). Those who were released were visited in their homes for administration of HIV and hepatitis tests. Positive tests were confirmed by another test (AUSYME MONOCLONAL and Western Blot). Mothers were also tested to detect vertical transmission. 256 patients had been transfused, of whom 61 died. 80 of the 195 remaining patients could not be located. Of the 115 patients located, 52 had died in their homes after release from the hospital. Thus, the sample comprised 63 patients: 36 were 0-3 years old, 21 were 4-7 years old, and 6 were 8-11 years old. 50 lived in rural and 13 in urban areas. 56 patients had one transfusion and 4 had two transfusions. 28 patients had transfusion for anemia, 19 for malnutrition, 7 for sepsis, 6 for various reasons (meningitis, pleuritis, pneumonia), and 3 for sickle cell disease. 47 patients had been transfused at the hospital using the blood bank, 13 used blood from relatives, and 3 received blood from friends. Out of the 63 samples processed, 2 patients presented seropositivity for hepatitis B, while none were seropositive for HIV. Among the 2 patients who were seropositive for hepatitis B, the mother of one of them was also seropositive.
Arch Domin Pediatr
PMID:[Human immunodeficiency virus and hepatitis B virus in children transfused in the Dr. Luis Manuel Morillo King Hospital]. 1234 60