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Query: UMLS:C0243026 (sepsis)
 52,417 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A characteristic intermittent neutrophilic dermatosis, associated with polyarthritis, tenosynovitis, malaise, fever, and cryoglobulinemia, occurs in 20% of patients who undergo ileojejunal bypass surgery for the treatment of morbid obesity. The clinical syndrome may mimic gonococcal sepsis. The histologic changes in the skin are those of Sweet's syndrome. The syndrome remits spontaneously in most cases, but it may recur intermittently over a period of years. Treatment with low-dose steroids, tetracycline, or metronidazole suppresses symptoms in most cases, and restoration of normal bowel anatomy is curative. Skin testing with Streptococcus pyogenes antigen causes an excerbation of symptoms, or may provoke the entire syndrome de novo. Bacterial peptidoglycans, especially those of group A streptococci, produce similar arthritis and skin lesions in animal models. Peptidoglycans from numerous intestinal bacteria share common structural and antigenic features with S. pyrogenes peptidoglycan and are suggested as causative of the toxic and immunologic features of this syndrome.
J Am Acad Dermatol 1980 Jun
PMID:The bowel bypass syndrome: a response to bacterial peptidoglycans. 740 Apr 4

Indurated, erythematous plaques of the left arm and left flank developed in a 69-year-old white man with multiorgan failure from Escherichia coli sepsis. Cutaneous malacoplakia was diagnosed. Intravenous antibiotic therapy resulted in resolution of the malacoplakia and the E. coli sepsis.
J Am Acad Dermatol 1994 May
PMID:Cutaneous malacoplakia. 751 27

A normally fit European resident of East Africa developed a staphylococcal peri-nephric abscess following repeated episodes of furuncular myiasis caused by the tumbu fly, Cordylobia anthropophaga. A few lesions had required surgical intervention and one, presumably the source of sepsis, had become infected. There are very few descriptions in the literature of serious complications of myiasis and this is the first report of peri-nephric abscess from this source. This paper discusses the management of the myiasis and what factors determine the variation in host susceptibility and immune response to the infestation.
Clin Exp Dermatol 1995 May
PMID:Troublesome myiasis complicated by peri-nephric abscess. 767 23

Toxic epidermal necrolysis (TEN) is a rare condition in childhood usually attributed to drugs. We describe a 4-month-old infant who developed typical clinical and histologic findings of TEN concomitantly with Klebsiella pneumoniae sepsis. We emphasize that in cases of acute, severe exfoliative disease in infants, apart from staphylococcal infection, gram-negative bacterial sepsis must also be considered.
Pediatr Dermatol 1994 Dec
PMID:Toxic epidermal necrolysis associated with Klebsiella pneumoniae sepsis. 789 84

We report a case of follicular keratosis with inflammatory changes, consistent with a diagnosis of atypical juvenile pityriasis rubra pilaris. An unusual feature was the occurrence of severe Staphylococcus aureus folliculitis and furunculosis, a phenomenon rarely encountered in pityriasis rubra pilaris and the other follicular keratoses. Standard antibiotic and antiseptic treatment for chronic S. aureus infection was ineffective. The patient was subsequently found to have hypogammaglobulinaemia, and treatment with human polyvalent immunoglobulin infusions was successful in eradicating the sepsis. It is therefore probable that the hypogammaglobulinaemia played a pathogenic role in the development of cutaneous sepsis.
Br J Dermatol 1994 Nov
PMID:Juvenile pityriasis rubra pilaris associated with hypogammaglobulinaemia and furunculosis. 799 8

Pityrosporum ovale is a lipophilic yeast that is part of the normal human adult cutaneous flora. It is both a saprophyte and an opportunistic pathogen associated with pityriasis versicolor, Pityrosporum folliculitis, seborrheic dermatitis, and some forms of atopic dermatitis. Systemic infections have also been described. In this article the diagnosis and management of pityriasis versicolor, Pityrosporum folliculitis, seborrheic dermatitis, and atopic dermatitis will be discussed.
J Am Acad Dermatol 1994 Sep
PMID:Pityrosporum infections. 807 1

Purpura fulminans is a rare syndrome of progressive hemorrhagic necrosis of the skin that may present as a dermatologic emergency. It most commonly affects children during the convalescent phase of a streptococcal infection or a viral exanthem. In adults, it may be associated with sepsis or acquired causes. Its pathogenesis has challenged physicians for decades. It has been discovered that purpura fulminans is almost always associated with disseminated intravascular coagulation and can occur in subjects with inherited or acquired deficiencies of the protein C anticoagulant pathway. Patients with liver compromise may also be potential candidates for coagulopathies secondary to hepatic dysfunction and impaired protein synthesis. It is widely recognized that individuals who consume alcohol on a long-term basis may develop severe hepatotoxicity from ingestion of therapeutic doses of acetaminophen (500 to 1000 mg every 4 to 6 hours). We have observed a patient with chronic alcoholism in whom hepatotoxicity and purpura fulminans developed secondary to the ingestion of acetaminophen.
Arch Dermatol 1993 Oct
PMID:Acquired purpura fulminans induced by alcohol and acetaminophen. Successful treatment with heparin and vitamin K. 821 90

Bullous lesions associated with non-01 Vibrio cholerae developed in a patient with hepatic cirrhosis who had recently ingested raw oysters. He died of overwhelming sepsis despite 5 days of aggressive antibiotic therapy. Non-01 V. cholerae was isolated from blood, peritoneal fluid, and bullae. The organism produced a cytotoxic factor that destroyed Chinese hamster ovary cells. Although septicemia caused by non-01 V. cholerae is uncommon, cutaneous manifestations of this organism are even rarer. Our patient represents the first reported case of bullous lesions associated with non-01 V. cholerae septicemia.
J Am Acad Dermatol 1993 Nov
PMID:Fatal septicemia and bullae caused by non-01 Vibrio cholerae. 840 40

We describe three neonates who had large eroded areas of skin on their extremities. The clinical course and ultrastructural findings were consistent with a diagnosis of epidermolysis bullosa herpetiformis (Dowling-Meara type). In each case blisters developed around eroded areas after birth and enlarged centrifugally in a herpetiform fashion. One patient died of sepsis at 8 days of age. In the two survivors blister formation subsided gradually within 1 year. Ultrastructural studies confirmed intraepidermal blister formation associated with spheric aggregates of tonofilaments in the lower epidermis. Spheric aggregates were also found in clinically uninvolved skin.
J Am Acad Dermatol 1993 May
PMID:Three neonatal cases of epidermolysis bullosa herpetiformis (Dowling-Meara type) with severe erosive skin lesions. 849 81

During 1982-1992, physicians at the Johannesburg General hospital in South Africa treated 49 patients aged 23-59 with biopsy-confirmed Kaposi's sarcoma (KS). Single chemotherapeutic agents used included vinblastine, actinomycin D, bleomycin, and vincristine. Most combined regimens used included doxorubicin/vincristine/bleomycin or etoposide/methotrexate. 17 patients, all of whom were men, had endemic African KS (AKS). 32 patients had AIDS-related KS. 58% of AKS patients experienced partial remission. 23% experienced complete remission compared to none of the patients with AIDS-related KS. 19% of AKS patients experienced complete treatment failure and died quickly. Deteriorating performance status or debilitating side effects (e.g., severe mucositis and neutropenic sepsis) necessitated completion of therapy in most patients with AIDS-related KS. Opportunistic infections claimed the lives of many patients with AIDS-related KS. Any response to therapy among AIDS-related KS patients was of short duration. These findings indicate that AKS responds to chemotherapy, while AIDS-related KS does not. In fact, AIDS-related KS has a poor prognosis.
Int J Dermatol 1995 Oct
PMID:Chemotherapy for AIDS-related and endemic African Kaposi's sarcoma in southern Africa. 853 66


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