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Query: UMLS:C0243026 (sepsis)
 52,417 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An association between clostridial sepsis and malignancy is well established in the literature. Although anaerobes are a relatively infrequent cause of renal abscess, there have been recent reports of anaerobic abscesses occurring in renal tumor masses. The present report describes a case of sepsis due to Clostridium perfringens infection of a locally recurrent renal cell carcinoma. The infection may have originated either from tumor invasion of the adjacent bowel or by hematogenous seeding of the mass at the time of colonoscopy. Patients with bulky, necrotic tumors who have invasive diagnostic procedures relating to either the gastrointestinal or urogenital tracts, as well as those having malignancies involving these systems, are at increased risk of infection with bowel anaerobes. Clostridial abscesses with accompanying sepsis occur in this setting, and empiric antibiotic regimens should include coverage for these organisms. Early, aggressive surgical intervention is essential.
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PMID:Clostridial infection of a locally recurrent renal cell carcinoma with sepsis. 236 71

Pancreatic infection is associated with high morbidity and mortality. Drainage of the infection is the usual therapeutic approach. Clostridium perfringens infection can cause fulminant sepsis, but it rarely occurs within the pancreas. The case of a 76-year-old man with cystic pancreatic lesions in which sepsis developed after endoscopic ultrasound with fine-needle aspiration biopsy is described. The sepsis was managed with pancreatic resection and antibiotics. Clostridium perfringens was isolated from blood cultures and microbiologic smears from the pancreas. Invasive intraductal papillary mucinous neoplasm with lymph node involvement was identified on histologic examination. The patient made a complete recovery from surgery without complications.
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PMID:Completion pancreatectomy for treatment of a Clostridium perfringens pancreatic infection. 1938 Jun 51